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Online Journal of Bioinformatics ©
Volume 16 (2): 188-193, 2015.
Predicting evolution of coloured vision in mammals through systems biology.
1Shivani Sharma, 2Prashant Saxena
1Life Sciences, Institute of Applied Medicine and Research, Duhai, Ghaziabad, Uttar Pradesh, 2Bioinformatics, Sathyabama University, Chenna, Tamilnadu, India.
Sharma S, Saxena P., Predicting evolution of coloured vision in mammals through systems biology, Onl J Bioinform., 16 (2): 188-193, 2015. Since Darwin, genetic change was considered to be a direct indicator of variation in phenotype. More recently, epigenetic developmental processes have been proposed to affect phenotype, thus shifting focus from a linear genotype-phenotype map to a non-linear one. Long wave sensitive (LWS) opsin gene plays a role in trichromatic vision in humans and other mammals sensitive to the green-yellow range which differentiates between vivid colours more clearly. We describe evolution of colour vision in mammals through mutations of LWS gene leading to different phenotypes. LWS, MWS and SWS opsin genes contribute to the variable colour vision spectrum. Authors show why genotypic variation alone may not be responsible for genotypes in vision and that it is possible that epigenetic developmental events such as gene conversion, recombination errors or chimeric genes may have contributed to current genotypes.
Keywords: Evolution, Opsin gene, genotype, phenotype, colour vision.