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OJBTM
Online Journal of Bioinformatics ©
Volume 16 (2): 188-193, 2015.
Predicting evolution of coloured
vision in mammals through systems biology.
1Shivani Sharma, 2Prashant Saxena
1Life Sciences, Institute of Applied Medicine
and Research, Duhai, Ghaziabad, Uttar Pradesh, 2Bioinformatics,
Sathyabama University, Chenna,
Tamilnadu, India.
ABSTRACT
Sharma S, Saxena P., Predicting
evolution of coloured vision in mammals through systems biology, Onl J Bioinform., 16 (2): 188-193, 2015. Since
Darwin, genetic change was considered to be a direct indicator of variation in
phenotype. More recently, epigenetic developmental processes have been proposed
to affect phenotype, thus shifting focus from a linear genotype-phenotype map to
a non-linear one. Long wave sensitive (LWS) opsin gene plays a role in
trichromatic vision in humans and other mammals sensitive to the green-yellow range
which differentiates between vivid colours more clearly. We describe evolution
of colour vision in mammals through mutations of LWS gene leading to different phenotypes.
LWS, MWS and SWS opsin genes contribute to the variable colour vision spectrum.
Authors show why genotypic variation alone may not be responsible for genotypes
in vision and that it is possible that epigenetic developmental events such as
gene conversion, recombination errors or chimeric genes may have contributed to
current genotypes.
Keywords: Evolution, Opsin gene, genotype, phenotype, colour
vision.