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OJBTM
Online Journal of Bioinformatics ©
Volume 16 (1): 8-17, 2015.
Modelling
simulation phylogenetics of leukemia FMS tyrosine
kinase 3 (FLT3).
Peddanna Kotha, Jayasimha Rayalu Daddam2*, Venkata
Ramana Sai Gopal Divi3, Subba Rao
Dakinedi4, Muralidhararao
Dowlathabad5
1,3DST-PURSE, Sri Venkateswara
University, Tirupati, A.P. INDIA, 2Department
of Biotechnology, JNTUA, Anantapur, A.P. INDIA, 4Department of Chemical Engineering, JNTUA College of Engeneering, Anantapur, A.P.
INDIA, 5Department of
Biotechnology, Sri Krishnadevaraya University, Anantapur, A.P. INDIA.
ABSTRACT
Kotha P, Rayalu Daddam J, Sai Gopal Divi VR, Dakinedi SR, Dowlathabad M., Modelling simulation phylogenetics
of leukemia FMS tyrosine kinase 3 (FLT3). Onl J Vet
Res., 16 (1): 8-17, 2015.
Acute Mylenoid
Leukemia, a blood and bone marrow cancer is characterized by abnormal
proliferation of white blood cells. Genes regulating heamatopoiesis
can alter susceptibility to Leukemia. FMS like-tyrosine kinase-3 (FLT3) plays a
key role in cell proliferation and differentiation. A three dimensional model
of FLT3 was generated using 1RJB (Chain A: Crystal structure of Juxta membrane domain of FLT3), as a template with
Modeller7v7. With the aid of molecular mechanics and dynamic methods a model was
generated checked by Procheck and 3D graph. After
energy minimization, the 3D structure of FLT3 was compared with a template, and
21 genes coding for FLT3 and their locus regions were identified. Multiple alignment
and phylogenetic analysis showed that FLT3 family proteins had 4 branches. Functional
mutations within FLT3 domain region were identified.
KEY WORDS:
Acute mylenoid Leukemia, FLT3, Modelling, Molecular
Dynamics, Phylogentic analysis.