©1996-2016. All Rights Reserved. Online Journal
of Bioinformatics . You
may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties.
Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from
the publisher. This article is exclusively copyrighted in its entirety to OJB
publications. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the
editors. This journal
satisfies the refereeing requirements (DEST) for the Higher Education Research
Data Collection (Australia). Linking: To link to this page
or any pages linking to this page you must link directly to this page only here
rather than put up your own page.
OJBTM
Online
Journal of Bioinformatics ©
Volume 16 (2): 179-187, 2015.
Antibacterial
activity and molecular
docking in Musa paradisiaca
flavonoids.
Jaya Sree1, Shravan Kumar Gunda2
1University
College of Science, 2Bioinformatics Division, Osmania University,
Hyderabad, Telangana State, India
ABSTRACT
Sree J, Gunda SK.,
Antibacterial activity and molecular docking in Musa paradisiaca
flavonoids, Onl J Bioinform.,
16
(2): 179-187, 2015. We describe anti-bacterial activity and In Silico molecular
docking in flavonoids from extracts of Musa paradisiaca
(Banana). Extract concentrations were determined by colorimetry
against a standard cyaniding curve yielding 71 ug/ml flavonoid
in methanol and 63 ug/ml in acetone. Extracts were screened against Pseudomonas marginalis , Pseudomonas aeroginosa,
Bacillus cereus, Proteus vulgaris, Staphylococcus aureus and Micrococcus luteus.
Results suggested inhibitory activity against bacteria. Molecular
docking studies were done with Autodock tools ligands
were sketched and energy minimization was performed in Sybyl
6.7, and molecules minimized
with Gasteiger-Huckel charges. Amino
residues interact with flavonoid inhibitors in the 2C1X binding site which could
be responsible for selectivity in flavonoid inhibitors.
Keywords:
Musa paradisiaca,
antibacterial activity, flavonoids, molecular docking.