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OJBTM
Online Journal of Bioinformatics©
Volume 18(2):78-85,
2017.
Pathway analysis of sequences in Mycobacterium Tuberculosis and Leprae
Lakshmi
Pillai and Usha
Chouhan.
Department of Computational and
Integrated Science MANIT, Bhopal
ABSTRACT
Pillai
L, Chouhan U., Pathway analysis of sequences in
Mycobacterium Tuberculosis and Leprae. Onl J Bioinform., 18(2):78-85,
2017. We classify
Mycobacterium Tuberculosis and Mycobacterium Leprae
on carbon metabolism pathway from NCBI and Swissprot/Uniprot databank Expasy server
and Biocyc.org. Comparative
pathway analysis resulted in 182 pathways of M. leprae and 209 in M. tuberculosis, where 28 amino acid pathways were in M. leprae and 38 in
Mycobacterium tuberculosis. We found that M. leprae
metabolizes glucose, but other carbon sources are not metabolized for energy.
There are pseudogenes in M. leprae that correspond
to M. tuberculosis for proteins that enable bacteria to breakdown other
carbon sources such as acetate and galactose. Genes responsible
for H37Rv to grow in macrophage like trp D, pro C and
met C are possible drug target genes. The carbon metabolic pathway analysis suggests commonality
between M. tuberculosis and leprae pathways for
identification of drug targets.
Keywords: Mycobacterium Tuberculosis
(M.TB), M. Lepare, Pathway analysis, Fibrosis, Granuloma,
Axenically.
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