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OJBTM
Online Journal of Bioinformatics ©
Volume 16(3): 293-302, 2015.
S. Aravinth Vijay Jesuraj1*,
S. Marylin Jeya Praya2,
M. Ravikumar3
1Centre for Pharmaceutical
Sciences, JNT University, Kukatpally, Hyderabad 500
085, Telengana State, 2Faculty of
Pharmacy, Lincoln University College, 47301 Petaling
Jaya, Malaysia. 3Faculty of Pharmacy, Geethanjali College of Pharmacy, Cheerial,
Keesara, Telengana, India.
Vijay Jesuraj SA, Jeya Praya SM, Ravikumar M., Model of protein
docking l-glutaminase for anti-cancer activity, Onl J Bioinform., 16(3): 293-302, 2015. L-Glutaminase from Aeromonas veronii was modeled and evaluated for docking with open
eye software against B-cell lymphoma 2 (BCL2) involved in colon adenocarcinoma. A 3D
model of L-Glutaminase was generated using 2BY A as template with Modeller7v7. The
model was refined by Procheck and Verify 3D graph. ARG 18, THR15, LEU42
residues in L-glutaminase had strong hydrogen bonding with Iturin A. Docking revealed highest L-glutaminase
binding value of -201.59K.cal/mol and orientation in BCL-2 binding pocket surrounding
active site suggesting that it may inhibit BCL-2.
Key words: Cancer, L-Glutaminase, BCL-2, Modelling, Protein docking