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OJBTM
Online Journal of Bioinformatics ©
Volume 18(1):1-6, 2017
In-Silico human, cow and sheep milk alpha casein
S1, fibronectin, lactoferrin and lysozyme for prediction
of hypersensitivity and malnutrition in infants.
Jitesh Pandey, Shivani Sharma MSc
Wrignano Systems Pvt.
Ltd., Delhi; Batch of 2015, Department of Life Sciences, Institute of Applied Medicine
and Research, Duhai, Ghaziabad, Ottar
Pradesh, India
ABSTRACT
Pandey J, Sharma
S., In-Silico human, cow and sheep milk alpha casein S1, fibronectin, lactoferrin and lysozyme for prediction of hypersensitivity
and malnutrition in infants, Onl J Bioinform., 18(1):1-4, 2017. In developing Asia, ~2.6% of infants cannot digest
cow milk inducing CMA (cow milk allergy). In
silico human, cow and sheep alpha casein S1 protein, fibronectin, lactoferrin and lysozyme present in milk were predicted for
milk hypersensity and malnutrition in infants. To
identify protein structure, multiple sequence alignment by CLUSTALW2 was performed
to determine constraints imposed by structure and function on evolution of
whole protein milk families. Protein constituents were visualized with
PROTPARAM and prediction of secondary structure with GOR. We find that human
and sheep proteins share greater similarity by sequence identity and amino acid
content compared with cow milk. Cow milk
had a higher percentage of essential amino acid compared with other milk which may
explains why different milks are hyper-allergic and less nutritious compared with
each other.
KEYWORDS: Milk Protein, Casein Alpha S1, Lactoferrin, Fibronectin and Lysozyme, Secondary Structure
Prediction, Comparative Genomics.