Volume 24 (6):332-337, 2020.
Effect of Zingiber officinale Roscoe extract on diarrhea in Wistar rats.
Ammar Khalid Hammad and Ali H. Saliem
College of Veterinary Medicine, University of Baghdad, Iraq
Hammad AK, Saliem AH., Effect of Zingiber officinale Roscoe extract on diarrhea in Wistar rats, Onl J Vet Res., 24 (6):332-337, 2020. We gavaged 2 groups of six 200-250g Wistar rats each with diarrhea induced by castor oil with or without 100mg/kg Zingiber officinale Roscoe ethanolic extract daily for 5 days. Six controls were given distilled water. To assess diarrhea, we counted wet droppings hourly 1-5 hours and then daily to 5 days. To evaluate empty and filled intestinal weights we sacrificed another 18 rats treated as above after 2 hours to assess empty and filled intestinal weights. The extract was positive for alkaloids, flavonoids, steroids, carbohydrates, glycosides, phenolic compounds, tannins and saponins but we found no amino acids or protein. Compared with controls, rats given castor oil expelled liquid feces up to 3 h whereas those given Zingiber officinale Roscoe it reduced (P < 0.05) 46-100%, 5h to 5 days after. Intestinal contents (g) reduced (P < 0.05) 58% in those given oil but only 15% in rats given extract with oil. Intestinal volumes (ml) fell (P < 0.05) 63% in rats given castor oil but only 36% in those given the oil with extract.
Key words: Diarrhea, Zingiber officinale, rats.