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OJVRTM
Online Journal of Veterinary
Research©
Volume 24 (5):281-283,
2020.
Effect of zinc on Trichomonas
vaginalis and antioxidant enzymes in
Vitro.
Maral Payedar1, Seyed Mostafa Razavi1 ,
Saeed Nazifi2
1Department(s) of Pathobiology, 2Clinical
Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
ABSTRACT
Payedar M, Razavi SM, Nazifi S., Effect of
zinc on Trichomonas vaginalis and antioxidant enzymes in Vitro, Onl J Vet Res., Volume 24 (5):281-283,
2020. Trichomonas vaginalis is a common
venereal infection often unsuccessfully treated with metronidazole. We report growth
and antioxidants in T. vaginalis cultured in Trypticase
-Yeast Extract-Maltose media with or without 100, 150, and 200 µg zinc/ml. Number
of parasites and glutathione peroxidase (GPX), superoxide dismutase (SOD) and
catalase (CAT), were determined 8 times 3 to 10 days post culture. Compared
with controls, in 100 µg/ml zinc enzymes increased (P < 0.05) 21-25%, parasites
4.5 fold, and protein 17%. At 150µg/ml, zinc had no effect on parasites or
enzymes but at 200µg/ml it appeared to eradicate T. vaginalis. We also
found a correlation (P <0.05; r = 0.72 between T. vaginalis and
protein. We conclude that at lower doses
(100µg/ml) actually enhances T vaginalis. We surmise that unsuccessful treatment
with metronidazole in patients given zinc supplementation may be due to higher
antioxidant resistance to free radicals and not drug resistance per se.
Keywords: Zinc,
T. vaginalis, metronidazole, antioxidant enzymes.
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