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OJVRTM

Online Journal of Veterinary Research

 

Volume 26 (6): 470-476, 2022.


Effect of Zataria multiflora boiss on intestinal ischemia-reperfusion in rats.

 

Naghmeh Ghasemkhani DVM, Omid Azari DVM PhD, Reza Kheirandish DVM PhD.

 

School of Veterinary Medicine, Shahid Bahonar University of Kerman, Iran.

 

ABSTRACT

 

Ghasemkhani N, Azari O, Kheirandish R., Effect of Zataria multiflora boiss on intestinal ischemia-reperfusion in rats, Onl J Vet Res., 26 (6): 470-476, 2022. Authors report effect of Zataria multiflora boiss (ZM) ethanol extract on intestinal ischemia/reperfusion injury in male Wistar albino rats. Groups of 5 rats each were gavaged 200 and 400 ppm ZM daily for 7 days ppm then subjected to 45 min ischemia followed by 1h reperfusion by clamping and de-clamping abdominal aorta. Five shams were gavaged saline subjected to surgery without clamping and controls clamped but not given ZM. After trials the jejunum was removed for microscopy and injury scored 0 normal, 1-4 villi edema fragmentation or hemorrhage to 5 complete mucosal necrosis as per Chiu et al., (1970). In clamped untreated controls we found severe mucosal denudation or complete loss of villi and necrosis with score 4-5 whereas in treated non-clamped shams intestines remained normal. In rats gavaged ZM we scored lesions 1-4 and 1-3 but we found no differences between these treated groups. Findings suggest that Zataria multiflora ethanol extract may reduce lesions induced by ischemia.

Key words: Ischemia/reperfusion injury, Zataria multiflora, Intestine, Rat.


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