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OJVRTM
Online Journal of Veterinary Research ©
Volume 15 (3): 239-248, 2011. Redacted 2017.
Effect of human platelet rich plasma on bone healing in rabbits
Z Shafiei-Sarvestani1 DVM DVSc, A Meimandi Parizi2 DVM DVSc,
A, Oryan3 DVM, AS Bigham4
1,2Departments of Veterinary Surgery and Radiology, 3Veterinary
Pathobiology, School of Veterinary Medicine, Shiraz University and 4Veterinary
Surgery and Radiology, School of Veterinary Medicine, Shahrekord
University, Shahrekord, Iran.
ABSTRACT
Shafiei-Sarvestani
Z, Meimandi Parizi A, Oryan A, Bigham AS., Effect of
human platelet rich plasma on bone healing in rabbits, Onl
J Vet Res., 15 (3): 239-248, 2011. Platelet-rich plasma (PRP) is used to
stimulate bone formation in vivo. The effect of human PRP (xenogenic PRP) on new bone formation in diaphyseal
long bone defects in rabbits is described. A critical size defect (10 mm) in
the radial diaphysis was created in fully anaesthetized rabbits given human PRP
(treated = 6) or not (controls = 6). Radiographs of forelimbs were taken on the 1st
day and 2nd, 4th, 6th and 8th weeks
post surgery to evaluate bone formation, union and
remodeling. Operated radiuses were removed 56th post-surgery day and
evaluated for healing and biomechanical tests were conducted on the forearm.
Radiographic evidence and statistical tests suggested that human PRP (hPRP) promoted bone regeneration in the rabbit.
KEY WORDS:
human platelet-rich plasma, radius, xenogenic PRP,
bone healing, rabbit
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