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Online Journal of Veterinary Research©
Volume 22 (10):928-932, 2018.
†Hematology and serum liver enzymes in hemophilic A and Von Willebrand patients
with hepatitis B or C compared with normal subjects.
Shahad Q Al-Hamadiny1, Dr Kadhum J Gattia1, Dr Safaa A Faraj2
1Department of Biology, College of Science, 2College of Medicine University of Wasit, Iraq.
Al-Hamadiny SQ, Gattia KJ, Faraj SA., Hematology and serum liver enzymes in hemophilic A and Von Willebrand patients with hepatitis B or C compared with normal subjects, Onl J Vet Res., 22 (10):928-932, 2018. Hemophilia A and Von Willebrand (VW) are genetic diseases caused by a lack or defect in factor VIII and/or coagulation factors. We determined hematology and serum liver enzymes in patients with hepatitis C or B in 35 males with hemophilia type A, and 6 males and 9 females with Von Willebrandís syndrome. Normal controls included 13 males and 12 females. In Von Willebrand patients we detected hepatitis in 60% and in hemophiliacs 45.71%. Compared with normal controls, in hemophiliacs we found significant (P < 0.0001 to 0.03) (LSD) lower mean hemoglobin (HB) of 9%, packed cell volume (PCV) 5%, corpuscular volume (MCV) 15%, corpuscular hemoglobin (MCH) 16% and corpuscular hemoglobin concentration (MCHC) 10% but a 9% increase in Platelets (PLT) and no significant effect on red blood cell count (RBC). However, in Von Willenbrandís mean hematological values were HB -22%, PCV -18%, MCV -16% MCH -17% and MCHC -17% whereas PLTís were 14% higher and RBC -14% lower, being greater differences compared with hemophiliacs, possibly due to the fact that hemophilia A occurs only in males. Serum alanine transaminase was lower (78%) only in patients with Von Willebrand but changes in aspartate transaminase (~55%) and alanine phosphatase (~126%) were similar in both conditions.
Key Words: Hemophilia A, Von Willebrand, Liver enzymes, Bilirubin, Hepatitis B-C