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OJVRTM
Online Journal of
Veterinary Research©
Established 1994
ISSN 1328-925X
Volume 22 (10):928-932, 2018.
Hematology and serum liver enzymes
in hemophilic A and Von Willebrand patients
with
hepatitis B or C compared with normal subjects.
Shahad
Q Al-Hamadiny1, Dr Kadhum
J Gattia1, Dr Safaa
A Faraj2
1Department of Biology, College
of Science, 2College of Medicine University of Wasit,
Iraq.
ABSTRACT
Al-Hamadiny SQ, Gattia KJ, Faraj SA., Hematology and serum liver enzymes in hemophilic A
and Von Willebrand patients with hepatitis B or C
compared with normal subjects, Onl J Vet Res., 22
(10):928-932, 2018. Hemophilia A and Von Willebrand
(VW) are genetic diseases caused by a lack or defect in factor VIII and/or
coagulation factors. We determined hematology and serum liver enzymes in
patients with hepatitis C or B in 35 males with hemophilia type A, and 6 males
and 9 females with Von Willebrand’s syndrome. Normal
controls included 13 males and 12 females. In Von Willebrand
patients we detected hepatitis in 60% and in hemophiliacs 45.71%. Compared with
normal controls, in hemophiliacs we found significant (P < 0.0001 to 0.03)
(LSD) lower mean hemoglobin (HB) of 9%, packed cell volume (PCV) 5%,
corpuscular volume (MCV) 15%, corpuscular hemoglobin (MCH) 16% and corpuscular
hemoglobin concentration (MCHC) 10% but a 9% increase in Platelets (PLT) and no
significant effect on red blood cell count (RBC). However, in Von Willenbrand’s mean hematological values were HB -22%, PCV
-18%, MCV -16% MCH -17% and MCHC -17% whereas PLT’s were 14% higher and RBC
-14% lower, being greater differences compared with hemophiliacs, possibly due
to the fact that hemophilia A occurs only in males. Serum alanine transaminase
was lower (78%) only in patients with Von Willebrand
but changes in aspartate transaminase (~55%) and alanine phosphatase (~126%)
were similar in both conditions.
Key
Words: Hemophilia A, Von Willebrand, Liver enzymes,
Bilirubin, Hepatitis B-C
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