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Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Volume 26 (4): 242-254, 2022.
Genomic analyses of white spot syndrome virus for drug targets.
S. Jeevan Amos (MSc), Subhalaxmi Nayak (MSc) and K. Umadevi (PhD)*
DBT – BIF Programme, Department of Marine Living Resources, Andhra University, Visakhapatnam –530 003, A. P., India.
Amos SJ, Nayak S, Umadevi K., Genomic analyses of white spot syndrome virus for drug targets, Onl J Vet Res., 26 (4): 242-254, 2022. White spot syndrome virus (WSSV) is a devastating disease for shrimp aquaculture without known antiviral therapy. Availability of WSSV and shrimp proteome sequences has enabled analysis of protein sequences for the identification of drug and vaccine targets. Subtractive genomics was performed to identify novel drug targets in WSSV. We found 531 coding sequences with 128 non-homologous protein to pathogen with 28 unique essential genes predicted as putative drug targets by functional assignment support vector machine. Sub-cellular localization prediction revealed 11 proteins on outer membrane of pathogen as vaccine candidates.
Key Words: WSSV, Subtractive Genomics Approach, Novel drug targets, Functional family prediction, Sub Cellular Localization