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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 26 (4): 242-254, 2022.
Genomic analyses of white spot syndrome virus for
drug targets.
S. Jeevan Amos (MSc), Subhalaxmi Nayak (MSc) and K. Umadevi
(PhD)*
DBT – BIF Programme, Department of Marine Living Resources, Andhra
University, Visakhapatnam –530 003, A. P., India.
ABSTRACT
Amos SJ, Nayak
S, Umadevi K., Genomic analyses of white spot syndrome
virus for drug targets, Onl J Vet Res., 26 (4): 242-254, 2022. White spot syndrome virus (WSSV) is
a devastating disease for
shrimp aquaculture without known antiviral therapy. Availability of WSSV and
shrimp proteome sequences has enabled analysis of
protein sequences for the identification of drug and vaccine targets. Subtractive
genomics was performed to identify novel drug targets in WSSV. We found 531
coding sequences with 128 non-homologous protein to
pathogen with 28 unique essential genes predicted as putative drug targets by functional
assignment support vector machine. Sub-cellular
localization prediction revealed 11 proteins on outer membrane of pathogen as
vaccine candidates.
Key
Words: WSSV, Subtractive Genomics
Approach, Novel drug targets, Functional family prediction, Sub
Cellular Localization