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OJVRTM
Online Journal of Veterinary Research©
Volume 26 (6): 446-457, 2022.
Effects of genus juglans on amygdala kindling epilepsy
in male Wistar rats
Shaahin
Harandi MSc1,2,
Mehdi Abbasnejad PhD1, Javad
Mirnajafi-Zadeh PhD3,
Saeed Esmaeili-Mahani
PhD1, Khadije Esmaeilpour
MSc2, Majid Asadi-Shekaari PhD2,
Ali Mostafavi
PhD4, Vahid Sheibani
PhD2
1. Department of Biology, Faculty of Sciences, Shahid
Bahonar University of Kerman, Kerman, 2. Neuroscience Research Center, Kerman University of Medical
Sciences, Kerman, 3. Department of Physiology, Faculty
of Medical Sciences, Tarbiat Modares
University, Tehran, 4. Chemistry Department, Shahid
Bahonar University of Kerman, Kerman, Iran
ABSTRACT
Harandi
S, Abbasnejad M, Mirnajafi-Zadeh
J, Esmaeili-Mahani S, Esmaeilpour
K, Asadi-Shekaari M, Mostafavi
A, Sheibani V., Effects of genus juglans
on amygdala kindling epilepsy in male Wistar rats, Onl J Vet Res., 26 (6): 446-457, 2022. We report effect of dietary walnut genus juglans on amygdala kindling epilepsy
in male Wistar rats. Bi
stimulating and monopolar recording electrodes were planted in the right
basolateral amygdalas stereotaxically.
Groups of 6 rats each were gavaged daily powered walnuts
2 months before kindling stimulations or injected weekly 4.5
ng intraperitoneal melatonin before kindling. Controls were subjected to
daily kindling or two-week IP saline before kindling. Walnuts decreased seizures
44-69% and duration of after-discharge about 3 fold (P < 0.02) over 13 days.
Results suggest that consumption of walnuts inhibited epilepsy. Pre ingestion
of 1.2g daily walnuts and 2-week injection of melatonin boosted serum melatonin
suggesting that the melatonin in walnuts may be responsible for these effects.
Keywords: Amygdala;
Epilepsy; Kindling; Melatonin; Seizure; Walnut.