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OJVRTM

Online Journal of Veterinary Research

 

Volume 26 (6): 446-457, 2022.


Effects of genus juglans on amygdala kindling epilepsy in male Wistar rats

 

Shaahin Harandi MSc1,2, Mehdi Abbasnejad PhD1, Javad Mirnajafi-Zadeh PhD3,

Saeed Esmaeili-Mahani PhD1, Khadije Esmaeilpour MSc2, Majid Asadi-Shekaari PhD2,

Ali Mostafavi PhD4, Vahid Sheibani PhD2

 

1. Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, 2. Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, 3. Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 4. Chemistry Department, Shahid Bahonar University of Kerman, Kerman, Iran

 

ABSTRACT

 

Harandi S, Abbasnejad M, Mirnajafi-Zadeh J, Esmaeili-Mahani S, Esmaeilpour K, Asadi-Shekaari M, Mostafavi A, Sheibani V., Effects of genus juglans on amygdala kindling epilepsy in male Wistar rats, Onl J Vet Res., 26 (6): 446-457, 2022. We report effect of dietary walnut genus juglans on amygdala kindling epilepsy in male Wistar rats. Bi stimulating and monopolar recording electrodes were planted in the right basolateral amygdalas stereotaxically. Groups of 6 rats each were gavaged daily powered walnuts 2 months before kindling stimulations or injected weekly 4.5 ng intraperitoneal melatonin before kindling. Controls were subjected to daily kindling or two-week IP saline before kindling. Walnuts decreased seizures 44-69% and duration of after-discharge about 3 fold (P < 0.02) over 13 days. Results suggest that consumption of walnuts inhibited epilepsy. Pre ingestion of 1.2g daily walnuts and 2-week injection of melatonin boosted serum melatonin suggesting that the melatonin in walnuts may be responsible for these effects.

 

Keywords: Amygdala; Epilepsy; Kindling; Melatonin; Seizure; Walnut.