2021-2033. All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


Online Journal of Veterinary Research


Volume 26 (6): 446-457, 2022.

Effects of genus juglans on amygdala kindling epilepsy in male Wistar rats


Shaahin Harandi MSc1,2, Mehdi Abbasnejad PhD1, Javad Mirnajafi-Zadeh PhD3,

Saeed Esmaeili-Mahani PhD1, Khadije Esmaeilpour MSc2, Majid Asadi-Shekaari PhD2,

Ali Mostafavi PhD4, Vahid Sheibani PhD2


1. Department of Biology, Faculty of Sciences, Shahid Bahonar University of Kerman, Kerman, 2. Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, 3. Department of Physiology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, 4. Chemistry Department, Shahid Bahonar University of Kerman, Kerman, Iran




Harandi S, Abbasnejad M, Mirnajafi-Zadeh J, Esmaeili-Mahani S, Esmaeilpour K, Asadi-Shekaari M, Mostafavi A, Sheibani V., Effects of genus juglans on amygdala kindling epilepsy in male Wistar rats, Onl J Vet Res., 26 (6): 446-457, 2022. We report effect of dietary walnut genus juglans on amygdala kindling epilepsy in male Wistar rats. Bi stimulating and monopolar recording electrodes were planted in the right basolateral amygdalas stereotaxically. Groups of 6 rats each were gavaged daily powered walnuts 2 months before kindling stimulations or injected weekly 4.5 ng intraperitoneal melatonin before kindling. Controls were subjected to daily kindling or two-week IP saline before kindling. Walnuts decreased seizures 44-69% and duration of after-discharge about 3 fold (P < 0.02) over 13 days. Results suggest that consumption of walnuts inhibited epilepsy. Pre ingestion of 1.2g daily walnuts and 2-week injection of melatonin boosted serum melatonin suggesting that the melatonin in walnuts may be responsible for these effects.


Keywords: Amygdala; Epilepsy; Kindling; Melatonin; Seizure; Walnut.