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OJVRTM
Online Journal of
Veterinary Research©
Volume 17 (4): 177-187, 2013
Effect of
walnut (Juglans
regia L) consumption on anticonvulsant low-frequency
stimulation in rats
Shaahin Harandi (MSc)1,2, Mehdi Abbasnejad (PhD)1, Javad
Mirnajafi-Zadeh (PhD)3,Khadije Esmaeilpour (MSc)2, Yaser
Masoumi (MSc)4,
Majid Asadi-Shekaari (PhD)2, Vahid Sheibani (PhD)2*
1Department of Biology, Faculty of Sciences,
Shahid Bahonar University
of Kerman, 2Neuroscience Research Center, Kerman University of
Medical Sciences, 3Department of Physiology, Faculty of Medical
Sciences, Tarbiat Modares
University, Tehran, and 4Physiology Research Center, Kerman
University of Medical Sciences, Kerman, Iran
ABSTRACT
Harandi S, Abbasnejad M, Mirnajafi-Zadeh J, Esmaeilpour K,
Masoumi Y, Asadi-Shekaari
M, Sheibani V., Effect of walnut (Juglans
regia L) consumption on anticonvulsant low-frequency
stimulation in rats, Onl J Vet Res., 17 (4): 177-187,
2013. In epilepsy, the anticonvulsant effects of
low-frequency stimulation (LFS) are time dependent. We report the effects of
1.2g daily walnut (Juglans
regia L) consumption after termination of
kindling (Immediate LSF), and after cessation of after-discharges (Delayed
LSF), on amygdaloid kindled seizures in male Wistar rats. Control and walnut consuming rats received
daily kindling and low-frequency monophasic square-wave pulses of 1 Hz, 100 µA,
0.1 ms per pulse every 15 min. Results indicate an
anti-convulsant effect of walnut pre-treatment in
kindled induced seizures Walnut consumption and immediate LFS reduced
electrical and behavioral parameters of kindling whereas delayed LFS had no
significant effect. There was no significant interaction between the
anticonvulsant effects of walnuts and LFS. Walnut consumption may have delayed
the kindling procedure but did not interact with LFS effects.
Keywords:
Epilepsy; Kindling; Low-frequency stimulation; Seizure; Walnut.
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