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Online Journal of Veterinary Research©
Effective (ED50) Thymus vulgaris anticoagulant dose in Wistar rats.
Ola Essam and Majida AJ Alqayim
Department of Physiology, Biochemistry and Pharmacology, College of Veterinary medicine, University of Baghdad, Iraq.
Essam O, Alqayim MA., Effective (ED50) Thymus vulgaris anticoagulant dose in Wistar rats, Onl J Vet Res., 25 (5): 350-353, 2021. Thymus vulgaris contains phytochemicals with antimicrobial and antioxidant properties. We report median effective dose of T vulgaris aqueous extract to prevent excessive coagulation in Wistar rats. Rats were intubated 25, 50, 75, 100, 200 mg/kg extract daily for 14 days weeks and gavaged 500mg/kg coagulant aminocaprioc acid (AA) twice every 6 hours. AA reduced bleeding time ~72% (P < 0.05) in control rats not given T vulgaris but with extract reduced it only ~-21 to 51% (P < 0.05). We calculated effective (ED50) of 75mg/kg. T. vulgaris increased plasma activated partial thromboplastin 41-61% (P < 0.05) and prothrombin 41-53%. Findings suggest that T. vulgaris may exert anticoagulant activity in rats via modulation of intrinsic and extrinsic coagulation factors.
Key words: Thymus vulgaris, coagulation, rats.