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OJVRTM
Online Journal of
Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 28(6): 327-338, 2024.
Effect of vitamin C on gentamicin-induced
nephrotoxicity in albino rats.
Amin
Derakhshanfar, Arash Bidadkosh, Ali Roshanzamir.
Department of Pathology, Faculty of Veterinary Medicine, Shahid Bahonar University of
Kerman, Kerman, Iran.
ABSTRACT
Derakhshanfar
A, Bidadkosh A, Roshanzamir
A., Effect of vitamin C on gentamicin-induced nephrotoxicity in albino rats, Onl J Vet Res., 28(6):
327-338, 2024. Groups
of 5 Albino rats were injected IM daily for 10 days 80 mg/kg gentamicin, with
100 or 200mg/kg vitamin C. Controls were injected saline. Gentamicin increased (P < 0.05) plasma MDA ~55% but
reduced creatinine clearance ~89%, serum
sodium ~61%, potassium 2% and cytoplasmic superoxide dismutase ~4%
compared with controls. Higher
doses of vitamin C (200 mg/kg/body wt) with
gentamicin decreased creatinine clearance ~32%, plasma MDA 37% and serum sodium ~21%. We found higher
doses of vitamic C reduced MDA further (P < 0.05)
compared with lower doses. Microscopy
revealed severe acute tubular necrosis in animals given gentamycin per se which
appeared to be ameliorated by vitamic C. Gentamicin-treated animals at a dose
of 80 mg/kg for 6 days demonstrated a typical pattern of nephrotoxicity
characterized by increased serum creatinine and necrosis of proximal tubular
epithelium. Findings suggest that high dose of vitamin C may inhibit functional
and histological renal changes induced by gentamicin in Albino rats.
Keywords: Gentamicin, vitamin C, nephrotoxicity,
rat, superoxide dismutase, peroxidation.
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