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 Online Journal of Veterinary Research

Volume 22 (7):587-595, 2018.

Effect of vitamin D on reproductive hormones, ovarian and uterine histology in Wistar rats gavaged aluminum chloride.


Shatha Q. Jaber and Tahani S.S. Al-Azawi PhD.


Department of Physiology & Pharmacology, College of Veterinary Medicine, University of Baghdad-Iraq.




Jaber SQ, Al-Azawi TSS., Effect of vitamin D on reproductive hormones, ovarian and uterine histology in Wistar rats gavaged aluminum chloride, Onl J Vet Res., (7):587-595, 2018. Groups of 5 Wistar rats each were gavaged 5000 IU vitamin D (VD) or 200mg/kg aluminum chloride (AL) daily for 15 days. Two other groups were gavaged VD for 15 days and then AL, for a further 15 days, or vice versa. Controls were given saline. Blood was taken at 15 and 30 days for determination of serum follicular stimulating, (LSH), luteinizing (LH), estradiol (E) and progesterone (P). At necropsy, ovaries and uterus were excised for microscopy and index values. Compared with controls (P < 0.05), serum FSH and progesterone were higher in rats given VD or VD before AL, LH and E were lower in all groups, ovarian index higher in all, and uterine index higher in those given VD. Compared with control microscopy, rats given vitamin D had prominent corpus luteum and aggregation of polymorphic nuclear cells on uterine stroma and adjacent glands. In rats given only aluminum chloride, we observed severe degenerative changes in primordial follicles and hemorrhage with congestion of the endometrium. Our results suggest that vitamin D may protect and/or induce regeneration of ovarian follicles before administration of aluminum chloride in Wistar rats.


Key words: vitamin D, Aluminum chloride, Female rats, reproductive system.