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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 27 (6): 386-396, 2023.

Function of vitamin C in various tissues.


Abolfazl Akbaria, Gholamali Jelodara , Javad Sajedianfarda and Saeed Nazifib


aDepartment of Physiology, bClinical Studies, School of Veterinary Medicine, Shiraz University, Shiraz, Iran




Akbari A, Jelodar G , Sajedianfard J, Nazifi S., Function of vitamin C in various tissues, Onl J Vet Res., 27 (6): 386-396, 2023. Authors describe functions of vitamin C in brain, neuroendocrine and adrenal tissues. L-ascorbic acid is reduced vitamin C and dehydroascorbic acid (DHA) is oxidized ascorbate, but both retain vitamin C activity. The vitamin is a co-factor for enzymes, regulates hypoxia-inducible factor 1α, antioxidant and pro-oxidants essential for reproduction and fertility. Ascorbate is a neuromodulator of glutamatergic, dopaminergic system and boosts immunity. The vitamin is transported into cells by sodium-dependent carriers which accumulate ascorbate against a concentration gradient. DHA is transported via glucose transporters and highest concentrations are found in brain, neuroendocrine and adrenal tissues. In brain, the vitamin is an essential co-substrate for hydroxylase and oxygenase reduction dopamine to nor-epinephrine and protects against glutamate toxicity. Ascorbic acid is essential for synthesis of hydroxyproline and hydroxylysine in collagen and enhances lymphocytes, chemotaxis, and delayed-type hypersensitivity.


Key words: Vitamin C, brain, adrenal, antioxidant, oxidative stress.