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OJVRTM
Online Journal of Veterinary Research©
Volume 26
(5): 357-364, 2022.
In vitro antibacterial activity of Vespa orientalis wasp
venom.
Jalaei
J MS PhD, Fazeli M DVM PhD, Rajaian H DVM PhD, Shomali T
DVM PhD.
Division
of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary
Medicine, Shiraz University, Shiraz, Iran.
ABSTRACT
Jalaei J, Fazeli M, Rajaian
H, Shomali T., In
vitro antibacterial activity of Vespa orientalis wasp
venom, Onl J Vet Res., 26 (5): 357-364, 2022. Venom Vespa orientalis wasp sac extract minimum inhibitory concentration (MIC) against
Staphylococcus intermedius, Bacillus
cereus, Pseudomonas
aeruginosa and Salmonella typhimurium was determined by microtiter
broth dilution and disk diffusion. Tetracycline was used as the positive control. Control
curves were compared with organisms grown in broth with 1 and 2 times MIC or 16
µg/ml tetracycline for 24 h. P. aeruginosa
was most resistant (50%) and S. typhimurium most sensitive to venom by
MIC. The antimicrobial activity of Vo venom against all tested bacteria was
concentration-dependent as demonstrated by growth curves. However compared with
tetracycline control ~32-128 times more vespa orientalis was required for equivalent inhibition. In
conclusion, Vo venom shows in vitro antibacterial activity against
S. intermedius, B. cereus, P.aeruginosa and S. typhimurium, although its MIC
values were much higher than tetracycline.
Key words: Vespa orientalis venom; antibacterial effect; in vitro
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