2021-2033. All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR. This article may be copied once but may not be, reproduced or re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (3): 156-170, 2023.


Disposition of adenine, synephrine, osthole and nicotinamide in nettle extract

 

Sloan Ayers, Bill Roschek, John M Williams, Randall S Alberte

 

HerbalScience Group LLC., Naples FL 34110, USA

 

ABSTRACT

 

Ayers S, Roschek R, Williams JM, Alberte RS., Disposition of adenine, synephrine, osthole and nicotinamide in nettle extract, Onl J Vet Res., 27 (3): 156-170, 2023. We determined disposition of adenine, synephrine, osthole and nicotinamide in a nettle (Urtica dioica) extract lozenge in human volunteers. Average serum adenine reached 35.2, nicotinamide 8.7, osthole 11.0 and synephrine 107.4nmol/l equivalent to 0.3, 0.2, 0.2 and 1.6% oral bioavailability. Urine levels reached 4.9, 2.5, 6.6 and 0.2 nmol/l, respectively. Compared with serum concentrations, in urine, Cmax decreased 2-16 fold, Tmax increased 2-12 and T1/2 increased 2-10. Molecular modeling revealed that these compounds were not likely to cross the blood-brain barrier, particularly important for the anti-histamine bioactives to ensure a non-drowsy activity. These results show that anti-inflammatory and anti-allergenic compounds in nettle are readily absorbed into the body and excreted in the urine when a nettle extract is delivered orally as a lozenge. In addition, DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.

 

Key Words: Urtica dioica, nettle, allergies, inflammation, DART TOF-MS


MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)