2021-2033 All Rights Reserved. Online Journal of Veterinary Research.  You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to onlinejournals@gmail.com publications. This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. Linking: To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


OJVRTM

Online Journal of Veterinary Research

Volume 25(1): 46-60, 2021.


Pharmacokinetics of anti-allergenic and anti-inflammatory bioactives

in nettle Urtica dioica extract oral lozenge in female volunteers

 

Ayers S, Roschek B Jr, Williams JM, Alberte RS.

 

Herbal Science Group LLC., Naples FL 34110, USA.

 

ABSTRACT

 

Ayers S, Roschek B Jr, Williams JM, Alberte RS., Pharmacokinetics of anti-allergy and inflammation bioactives in nettle extract Urtica dioica lozenge in female volunteers, Onl J Vet Res., 25 (1): 46-60, 2021. We report pharmacokinetics by Direct Analysis in Real Time Time-of-Flight Mass Spectrometry (DART TOF-MS) uptake of bioactives in a nettle (Urtica dioica) extract delivered orally as a lozenge. In five female healthy subjects, average serum concentrations of adenine reached 35.2 nmol L-1, nicotinamide 8.7 nmol L-1, osthole 11.0 nmol L-1 and synephrine 107.4 nmol L-1 equivalent to 0.3%, 0.2%, 0.2%, and 1.6% oral bioavailability. Urine concentrations reached 4.9 nmol L-1 adenine, 2.5 nmol L-1 nicotamide, 6.6 nmol L-1 osthole and 0.2 nmol L-1 synephrine. Cmax decreased 2-16 fold in urine compared with serum, Tmax increased 2-12 fold, and T1/2 by 2-10-fold. Molecular modeling suggested these compounds were not likely to cross the blood-brain barrier to avoid drowsiness. Our findings suggest that anti-inflammatory and anti-allergenic compounds in nettle are readily absorbed and excreted when given in an oral lozenge. DART TOF-MS is useful in quantifying multiple components in biological matrices with little or no sample preparation.

 

Key Words: Urtica dioica, nettle, allergies, inflammation, DART TOF-MS.


MAIN

 

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)