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Online Journal of Veterinary Research©
Volume 23 (11):1095-1103, 2019.
Accumulation of chronic uranyl nitrate hexahydrate in kidneys and histopathology in adult albino rats.
Ghusoon Abdul kareem Neamah (MSc)1, Eman Hashim Yousif (PhD)1,
Anees A. Hassan (PhD)2.
1Department of Pathology and Poultry Diseases, College of veterinary medicine, University of Baghdad, 2Department of Physics, College of Education, University of Al-Qadisiyah, Qadisiyah, Iraq
Kareem Neamah GA, Yousif EH, Hassan AA., Accumulation of chronic uranyl nitrate hexahydrate in kidneys and histopathology in adult albino rats, Onl J Vet Res., 23 (11):1095-1103, 2019. Uranium is a radioactive heavy metal toxic pollutant. Groups of 10 albino rats aged 8-10 weeks weighing 120 -200gm were gavaged 0.06 mg/kg or 0.12 mg/kg uranyl nitrate hexahydrate (UN) daily for 90 days. Controls were given distilled water. At day 90, kidneys were excised for histopathology and UN concentrations determined by CR-39 detector. We found dose dependent accumulation (P ≤0.01) of uranium in kidneys with severe vacuolation in glomeruli and tubular epithelia, atrophy of glomerular tufts with thickening in bowman's space, cystic dilation of renal tubules with interstitial fibrosis and inflammatory cells infiltration and thickening with lipid foamy cells formation in blood vessels. We find that chronic exposure to uranyl nitrate hexahydrate (UN) leads to high accumulation in glomeruli and tubular epithelia that could induce renal failure.
Key words: Uranyl nitrate hexahydrate, renal, residues, toxicity, histopathology, rat.