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OJVRTM
Online Journal of Veterinary Research©
Volume 23 (11):1095-1103,
2019.
Accumulation of
chronic uranyl nitrate hexahydrate in kidneys and histopathology in adult albino
rats.
Ghusoon Abdul kareem
Neamah (MSc)1, Eman Hashim Yousif
(PhD)1,
Anees A. Hassan (PhD)2.
1Department of Pathology
and Poultry Diseases, College of veterinary medicine, University of Baghdad, 2Department
of Physics, College of Education, University of Al-Qadisiyah,
Qadisiyah, Iraq
Kareem Neamah GA, Yousif
EH, Hassan AA., Accumulation of chronic uranyl nitrate hexahydrate in kidneys and
histopathology in adult albino rats, Onl J Vet Res., 23 (11):1095-1103, 2019. Uranium is a radioactive heavy
metal toxic pollutant. Groups of 10
albino rats aged 8-10 weeks weighing 120 -200gm were gavaged
0.06 mg/kg or 0.12 mg/kg uranyl nitrate
hexahydrate (UN) daily for 90 days. Controls were given distilled water.
At day 90, kidneys were excised for histopathology and UN concentrations
determined by CR-39 detector. We found dose dependent accumulation (P
≤0.01) of uranium in kidneys with severe vacuolation
in glomeruli and tubular epithelia, atrophy of glomerular tufts with thickening
in bowman's space, cystic dilation of renal tubules with interstitial fibrosis
and inflammatory cells infiltration and thickening
with lipid foamy cells formation in blood vessels. We find that chronic
exposure to uranyl nitrate hexahydrate (UN) leads to high accumulation in
glomeruli and tubular epithelia that could induce renal failure.
Key words: Uranyl nitrate hexahydrate, renal, residues, toxicity, histopathology,
rat.
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