2023-2035 All Rights Reserved. Online Journal of Veterinary Research . You may not store these pages in any form except for your own personal use. All other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the  before mentioned must be gained in writing from the publisher. This article is exclusively copyrighted in its entirety to OJVR.This article may be copied once but may not be, reproduced or  re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements (DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link directly to this page only here rather than put up your own page.


 OJVRTM

Online Journal of Veterinary Research  

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28 (2): 61-69, 2024.


Disposition of gatifloxacin after gavage in healthy and hepatopathic turkeys.

 

Kaushik Sarkar, Kumar Roy.

 

Department. of Pharmacology and Toxicology, College of Veterinary Science, Ranchi, India

 

ABSTRACT

 

Sarkar K, Roy K., Disposition kinetics of gatifloxacin after single oral administration in healthy and hepatopathic turkeys. Onl J Vet Res., 28 (2): 61-69, 2024. We report disposition kinetics of gatifloxacin single dose oral administration 20 mg/kg in 6 normal and 6 paracetamol induced hepatopathic 1-1.5 year 3-4 kg turkeys. Plasma Cpmax of 5.940.29 g/ml occurred at 2h in hepatopathic and 5.330.26 g/ml in normal turkeys whereas therapeutic levels remained 48 and 24h, respectively. Plasma tβ was extended to 11.520.20h compared with normal turkeys (6.260.45 h) but plasma ClB was 6.250.35 ml/kg/min compared with healthy ones (8.280.46 ml/kg/min). Mean Vdarea of gatifloxacin of 6.230.36 L/kg was higher (p<0.05) compared to healthy turkeys (4.940.28 L/kg). Results suggest that 12.52 mg/kg oral gatifloxacin could be administered at 88h intervals in hepatopathic turkeys.

 

Key words: Disposition kinetics, gatifloxacin, turkeys, hepatopathy, oral.


MAIN

 

FULL-TEXT (SUBSCRIBE OR PURCHASE TITLE)