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OJVRTM

 

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 28(4): 198-207, 2024.


Molecular Sequence Mycobacterium Tuberculosis and Leprae drug targets.

 

Lakshmi Pillai, Usha Chouhan.

 

Department of Computational and Integrated Science, MANIT, Bhopal.

 

ABSTRACT

 

Pillai L, Chouhan U., Molecular Sequence Mycobacterium Tuberculosis and Leprae drug targets, Onl J Vet Res., 28(4):198-207, 2024. Genus Mycobacterium consists of pathogenic M. tuberculosis and M. leprae with different proteins but similar characteristics. We describe computational classification of M. tuberculosis and Leprae drug targets based on protein properties and carbon pathway analysis. We found 28 amino acid pathways for Mycobacterium leprae and 38 for M. tuberculosis. For carbon metabolism pathways we found similarity and dissimilarities between the bacteria but M. leprae metabolizes glucose for energy and pseudogenes in M. leprae corresponding to genes in M. tuberculosis enable breakdown of other carbon source acetate and galactose. We found more pathways in M. tuberculosis suggesting more unknown genes in this organism compared with M. leprae. Pathways from M. leprae suggest this organism cannot grow axenically and depends on environment for growth whereas in M. Tuberculosis tryptophan and proline pathways are essential for growth in macrophages and may be useful drug targets.

Keywords: Mycobacterium Tuberculosis, M. Leprae, pathway analysis, fibrosis, granuloma.

 

Keywords: Mycobacterium Tuberculosis, M. Leprae, pathway analysis, fibrosis, granuloma.


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