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OJVRTM
Online Journal of Veterinary Research©
(Including Medical
and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28(4): 198-207,
2024.
Molecular
Sequence Mycobacterium Tuberculosis and
Leprae drug targets.
Lakshmi
Pillai, Usha Chouhan.
Department of Computational and
Integrated Science, MANIT, Bhopal.
ABSTRACT
Pillai L, Chouhan
U., Molecular Sequence Mycobacterium Tuberculosis and Leprae
drug targets, Onl J Vet Res., 28(4):198-207, 2024. Genus Mycobacterium consists of pathogenic M. tuberculosis and M. leprae
with different proteins
but similar characteristics. We describe
computational classification of M.
tuberculosis and Leprae
drug targets based on protein properties and carbon pathway analysis. We found 28
amino acid pathways for Mycobacterium leprae and 38 for
M. tuberculosis. For carbon
metabolism pathways we found similarity and dissimilarities between the
bacteria but M. leprae metabolizes
glucose for energy and pseudogenes in M. leprae
corresponding to genes in M. tuberculosis enable breakdown of other
carbon source acetate and galactose. We found more pathways in M. tuberculosis suggesting more unknown
genes in this organism compared with M. leprae. Pathways from M. leprae suggest
this organism cannot grow axenically and depends on
environment for growth whereas in M.
Tuberculosis tryptophan and proline pathways are essential for growth in
macrophages and may be useful drug targets.
Keywords: Mycobacterium
Tuberculosis, M. Leprae,
pathway analysis, fibrosis, granuloma.
Keywords: Mycobacterium
Tuberculosis, M. Leprae, pathway analysis,
fibrosis, granuloma.
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