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OJVRTM
Online Journal of Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 27 (6):
357-366, 2023.
Reverse vaccinology: tuberculosis.
Sriranjini AS BSc.
Department of Biotechnology, B.V.Bhoomaraddi College of Engineering & Technology, Hubli, India
ABSTRACT
Sriranjini AS., Reverse vaccinology
for tuberculosis, Onl J Vet Res., 27 (6): 357-366, 2023.
Author describes In silico reverse vaccine for Mycobacterium
tuberculosis by selection of antigen with less identity and E-value from
8000 proteins. Results suggested HRRAPL antigenic determinant was suitable by
docking analysis and Clustal W Dendrogram
of Mycobacterium H37RV
was closely related with M. Bovis and permease of M tuber with Borrelia garini.
HRRAPL sequence had only 22% similarity and its epitope bound with MHC I with
docking energy of 55.9.
Keywords:
Tuberculosis, Mycobacterium, Vaccinology, Epitope, Immune, Oesophagus.
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