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OJVRTM

Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X

 

Volume 27 (6): 357-366, 2023.


Reverse vaccinology: tuberculosis.

 

Sriranjini AS BSc.

 

Department of Biotechnology, B.V.Bhoomaraddi College of Engineering & Technology, Hubli, India

 

ABSTRACT

 

Sriranjini AS., Reverse vaccinology for tuberculosis, Onl J Vet Res., 27 (6): 357-366, 2023. Author describes In silico reverse vaccine for Mycobacterium tuberculosis by selection of antigen with less identity and E-value from 8000 proteins. Results suggested HRRAPL antigenic determinant was suitable by docking analysis and Clustal W Dendrogram of Mycobacterium H37RV was closely related with M. Bovis and permease of M tuber with Borrelia garini. HRRAPL sequence had only 22% similarity and its epitope bound with MHC I with docking energy of 55.9.

Keywords: Tuberculosis, Mycobacterium, Vaccinology, Epitope, Immune, Oesophagus.


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