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Online Journal of Veterinary Research©
Volume 24 (1):38-42, 2020.
Effect of guinea pig transfer factor cytokines on Mycobacterium bovis cell-mediated immunity in Friesian calves.
KA Khalifa1 and MM Jawad2
Medicine, Anbar University, 2Veterinary
Khalifa KA, Jawad MM., Effect of guinea pig transfer factor cytokines on Mycobacterium bovis cell-mediated immunity in Friesian calves, Onl J Vet Res., 24 (1):38-42, 2020. We tested transfer factor (TFS) cultured in guinea pigs against a Colmete-Guerin strain of Mycobacterium bovis to induce specific cell-mediated immunity in Friesian calves. In those given TFS leucocyte migration (MIF) ranged 48-85% whereas those injected non-immunized factor (TFN) ranged 68-120% (P < 0.05). By nitroblue tetrazolium test (NBT) phagocytic capacity in calves given TFS ranged 19-45% whereas in those given TFN only 8-15%. Skin reactivity as expressed by delayed type hypersensitivity was also significant in treated calves. Our results suggest that TFS induced cell-mediated immunity as shown In vivo dermal reaction and In vitro by leucocyte migration and phagocytosis tests.
Key words: Lymphocyte, Transfer factor, guine pig, cattle, immunity.