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OJVRTM

Online Journal of Veterinary Research

 

Volume 24 (1):38-42, 2020. 


 

 

Effect of guinea pig transfer factor cytokines on Mycobacterium bovis cell-mediated immunity in Friesian calves.

 

KA Khalifa1 and MM Jawad2

 

1College of Medicine, Anbar University, 2Veterinary Practitioner, Iraq,

ABSTRACT

 

Khalifa KA, Jawad MM., Effect of guinea pig transfer factor cytokines on Mycobacterium bovis cell-mediated immunity in Friesian calves, Onl J Vet Res., 24 (1):38-42, 2020. We tested transfer factor (TFS) cultured in guinea pigs against a Colmete-Guerin strain of Mycobacterium bovis to induce specific cell-mediated immunity in Friesian calves. In those given TFS leucocyte migration (MIF) ranged 48-85% whereas those injected non-immunized factor (TFN) ranged 68-120% (P < 0.05). By nitroblue tetrazolium test (NBT) phagocytic capacity in calves given TFS ranged 19-45% whereas in those given TFN only 8-15%. Skin reactivity as expressed by delayed type hypersensitivity was also significant in treated calves. Our results suggest that TFS induced cell-mediated immunity as shown In vivo dermal reaction and In vitro by leucocyte migration and phagocytosis tests.

 

Key words: Lymphocyte, Transfer factor, guine pig, cattle, immunity.


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