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OJVRTM
Online Journal of
Veterinary Research©
Volume 24 (1):38-42, 2020.
Effect of guinea pig transfer factor cytokines
on Mycobacterium bovis
cell-mediated immunity in Friesian calves.
KA Khalifa1 and MM Jawad2
1College of
Medicine, Anbar University, 2Veterinary
Practitioner, Iraq,
ABSTRACT
Khalifa KA, Jawad MM., Effect of guinea pig
transfer factor cytokines on Mycobacterium bovis cell-mediated
immunity in Friesian calves, Onl J Vet Res., 24 (1):38-42, 2020. We tested transfer factor (TFS) cultured in guinea
pigs against a Colmete-Guerin strain of Mycobacterium bovis
to induce specific cell-mediated immunity in Friesian calves. In those given
TFS leucocyte migration (MIF) ranged 48-85% whereas those injected
non-immunized factor (TFN) ranged 68-120% (P < 0.05). By nitroblue
tetrazolium test (NBT) phagocytic capacity in calves given TFS ranged 19-45% whereas in those given TFN only 8-15%. Skin
reactivity as expressed by delayed type hypersensitivity was also significant
in treated calves. Our results suggest that TFS induced cell-mediated immunity
as shown In vivo dermal reaction and In vitro by leucocyte migration and phagocytosis
tests.
Key words: Lymphocyte, Transfer factor, guine pig, cattle, immunity.
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