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OJVRTM
Online Journal of
Veterinary Research©
(Including Medical and Laboratory Research)
Established 1994
ISSN 1328-925X
Volume 28 (11): 798-807, 2024.
Molecular model Mycobacterium tuberculosis H37Rv Methionyl
S-adenosyl transferase.
Kishore VS, Kanthamma M, Swamy VK, Anuradha M, Kumar CS
Department of Biochemistry, Sri Krishnadevaraya
University, Anantapur, Andhra Pradesh, India.
ABSTRACT
Kishore VS, Kanthamma M, Swamy VK, Anuradha M, Kumar CS., Molecular model Mycobacterium tuberculosis H37Rv Methionyl S-adenosyl transferase,
Onl J Vet Res.,
28
(11): 798-807, 2024. Methionine
S-adenosyltransferase (MAT) synthetizes S-adenosylmethionine (SAM), methyl donor essential for mycolipid biosynthesis. As tuberculosis drug target, Mt-MAT we
constructed X-ray/NMR crystallographic for homology model of MAT from X-ray
structures of E.coli template by
comparing proteins. The model had correct stereochemistry by Ramachandran plot,
verified-3D score and PROCHECK. Our
homology model conserved topological and active features of the MAT family of
proteins.
Keywords: Methionine S-adenosyltransferase
(MAT), Mycobacterium tuberculosisH37Rv, Homology modeling.