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OJVRTM
Online Journal of Veterinary
Research©
Established 1994
ISSN 1328-925X
Volume 22 (10):871-876, 2018.
Blood
antibody-complement age profile in patients infected by Leishmania tropica and non-infected subjects.
1Abdulwahab
Bedawi Hussein, 2Ashwaq Talib Hameed, 3Shaymaa Shihab
Abdullah.
1Department of Clinical
Pathology, College of Applied Sciences, University of Fallujah, 2,3Education
College For Women, University of Anbar.
ABSTRACT
Hussein
AB, Hameed AT, Abdullah SS., Blood antibody-complement age profile in patients
infected by Leishmania tropica
and non-infected subjects, 22 (10):871-876, 2018., Blood was taken
from thirty 10-20,
20-35 and 35-50 year old male and female patients infected by Leishmania tropica and non-infected control
subjects. Groups consisted of 5 individuals in each age group. Blood IgA,
IgG, IgM and IgE and complement C3 and C4 were
determined by ELISA in the 30 subjects. Blood antibody and C3 levels subjects
infected by L. tropica
were higher (P < 0.05) compared with non-infected subjects. However, in
infected persons, we found no significant differences in serum
antibody-complement levels between any age group. Antibody responses were
greater in young infected subjects compared with young non-infected controls.
Serum IgA values were ~56%, IgG ~85 and IgM ~59% higher (P < 0.05) in young
infected persons. We detected a large
~28 fold higher difference (P < 0.05) in serum IgE
in younger infected patients compared with controls suggesting that this
antibody is most reactive to L. tropica. High serum IgE
values also occurred in older infected age groups. Our findings confirm that Leishmania tropica
induces humoral immunity.
Key
words: Leishmania
tropica, immunoglobulins,
complements, raw data supplied.