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Online Journal of Veterinary Research©
Volume 22 (10):871-876, 2018.
Blood antibody-complement age profile in patients infected by Leishmania tropica and non-infected subjects.
1Abdulwahab Bedawi Hussein, 2Ashwaq Talib Hameed, 3Shaymaa Shihab Abdullah.
1Department of Clinical Pathology, College of Applied Sciences, University of Fallujah, 2,3Education College For Women, University of Anbar.
Hussein AB, Hameed AT, Abdullah SS., Blood antibody-complement age profile in patients infected by Leishmania tropica and non-infected subjects, 22 (10):871-876, 2018., Blood was taken from thirty 10-20, 20-35 and 35-50 year old male and female patients infected by Leishmania tropica and non-infected control subjects. Groups consisted of 5 individuals in each age group. Blood IgA, IgG, IgM and IgE and complement C3 and C4 were determined by ELISA in the 30 subjects. Blood antibody and C3 levels subjects infected by L. tropica were higher (P < 0.05) compared with non-infected subjects. However, in infected persons, we found no significant differences in serum antibody-complement levels between any age group. Antibody responses were greater in young infected subjects compared with young non-infected controls. Serum IgA values were ~56%, IgG ~85 and IgM ~59% higher (P < 0.05) in young infected persons. We detected a large ~28 fold higher difference (P < 0.05) in serum IgE in younger infected patients compared with controls suggesting that this antibody is most reactive to L. tropica. High serum IgE values also occurred in older infected age groups. Our findings confirm that Leishmania tropica induces humoral immunity.
Key words: Leishmania tropica, immunoglobulins, complements, raw data supplied.