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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28(3): 156-162, 2024.

Effect of Triganella foenum graecum gavage on sperm and serum thyroid hormones

in hypothyroid and normal Albino mice.


Fouad Ziedan Hamza Al-Quraishi, Bassam Abdulameer Mohammed A-Madany, Mohammed Abdaljaleel Fadhel Al-Kraawi, Nadia K. J. Al-Dawah


Department of Physiology, Pharmacology and Chemistry, College of Veterinary Medicine, University of Kufa, Kufa, Iraq.



Hamza Al-Quraishi FZ, Mohammed A-Madany BA, Fadhel Al-Kraawi MA, Al-Dawah NKF., Effect of Triganella foenum graecum gavage on sperm and serum thyroid hormones in hypothyroid and normal albino mice, Onl J Vet Res., 28(3): 156-162, 2024. We report effect of Triganella foenum graecum (Fenugreek) and thyroxin in normal and hypothyroid albino mice on sperm and serum thyroid stimulating, thyroxine and triiodothyronine hormones. Mice were gavaged 15mg/kg fenugeek or injected 0.1mg/kg thyroxin introperitoneally daily for 30 days. Normal and hypothyroid controls were gavaged? Saline. We determined serum hormones by ELISA and RIA kits and semen motility, progressive motility, viability and morphology from epidimal samples. Compared with normal controls, hypothyroid controls were associated with enhanced serum TSH (~65%) and reduced T3 and T4 (-62-73%) (P < 0.05) whereas hypothyroid mice given thyroxin with or without feenugeek had reduced TSH but maintained normal serum T3 and T4 levels. Hypothyroid mice had reduced sperm count, motility and viability whereas trhyroxin and fenugreek was associated with increased values.


Key words: Hypothyroidism, Sperm, Thyroxine, Fenugreek, Mice.