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Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X

 

Volume 29 (3): 160-166, 2025.

Hematology, serum kidney and hepatic enzymes in dogs after acute 2-5mg/kg intramuscular tramadol injections.

 

Baharak Akhtardanesh DVM PhD, Hamid Sharifi DVM PhD, Rokhsana Rasouli DVM, Maryam Aghazamani DVM.

 

Faculty of Veterinary Medicine,  Shahid-Bahonar University of Kerman,  Iran.

 

ABSTRACT

 

Akhtardanesh B, Sharifi H, Rasouli R, Aghazamani M., Hematology, serum kidney and hepatic enzymes in dogs after acute 2-5mg/kg intramuscular tramadol injections.  Onl J Vet Res., 29 (3): 160-166, 2025. Tramadol a synthetic centrally acting opioid analgesic, can be administered without excessive sedation or side effects for postoperative pain relief in dogs. White (WBC), red blood cell (RBC) and serum hepatic (ALT, ASP, ALP) enzymes and Kidney function markers creatinine and blood urea nitrogen (BUN) values in healthy 14-22 month old mongrel dogs given 2 and 5 mg/kg IM acute tramadol administration once daily for 3 days are reported. Controls were given IM saline. Dogs were sampled at day 0, 4 and 11. Mean RBC in controls was 6 X 106 and in dogs injected 5mg 5.8 X 106 T. Same values for WBC were 8.6 and 6.4 X 104, for ALT 42 and 45.7 IU, AST 21.7 and 43.3 IU, ALP 78.3 and 66.7 IU, creatinine 0.9 and 1.0 mg/dl, BUN 27 and 21.3 mg/dl and for PCV 38.7 and 39.6%.  We found no significant (P > 0.05) in any mean value.

 

Key words: Dog, Tramadol, toxicity, liver, kidney, hematology.

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