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OJBTM
Online Journal of Bioinformatics ©
Volume
12(2):371-378, 2011
In
silico T cell antigens from proteome
of H1N2 swine influenza A
virus
Sitansu Kumar Verma*,
Shivam Pratap
Singh Yadav and Ajay Kumar
Department of Biotechnology,
Institute of
Biomedical Education and Research, Mangalayatan
University, Aligarh (U.P), India
ABSTRACT
Verma SK, Singh Yadav
SK, Kumar A.,
In silico T cell antigenic determinants
from proteome
of H1N2 swine influenza A virus, Online J Bioinformatics, 12(2):371-379,
2011. In silico peptides for development of
vaccines
against swine influenza H1N2 are described. Propred and Propred
I were used to predict
T
cell epitopes from hemagglutinin, neuraminidase,
polymerase, polymerasebasic 1,
polymerase 2, matrix
protein 1, matrix protein
2, nonstructural protein 1,
nonstructural protein 2, and nucleocapsid protein of influenza virus (A/Sw/It/116114/2010)
(H1N2). A 4% threshold was used to
select high binding
affinity peptides. A total of 21 epitopes
were
predicted for HLA class I and 20 epitopes
for HLA class II molecules. These T
cell epitopes were top scoring peptides
and bound with the maximum number of HLA alleles.
Keywords:
T cell epitope, Propred,
Influenza A virus (H1N2), Human Leukocyte antigen.