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OJVRTM
Online Journal of Veterinary Research©
Volume 17 (1): 1-9, 2013. Redacted 2017.


Pathogenicity of subtype H9N2 virus in broiler chicks with bursal disease

 

  M. Mayahi¹, M Seifiabad Shapouri², RA Jafary¹, A khodadadi, S Dibavand1, N Motamad¹*

 

¹Avian Diseases and ²Virology, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Iran

 

ABSTRACT

 

Mayahi M, Shapouri MS, Jafary RA, Khodadadi A, Dibavand S, Motamad N., Pathogenicity of subtype H9N2 virus in broiler chicks with bursal disease, Online J Vet Res.,  17 (1): 1-9, 2013. The pathogenicity of subtype H9N2 avian influenza virus (LPAI) in broiler chicks experimentally infected with bursal disease (BD) is described.  Broiler chicks were infected with 103 CID50 of BD virus via the bursa at 1 day of age and 106 EID50 subtype H9N2 virus via intranasal and intraocular routes at day 30. Tissue samples were collected at days 3, 7 and 11 post-infection (PI).  Isolation of virus in embryonated eggs and RT-PCR suggests that IB induced AIV in brain and liver. Moreover, virus in trachea, conjunctiva, bursa and lung in IBD+AIV infected birds was detected for 11 days PI. RT-PCR detected virus in the kidneys longer than the virus isolation method. Results suggest that IBDV infection may induce greater susceptibility to avian influenza virus infection and pathogenic effects of LPAI viruses.

 

Key words: Infectious bursal disease, Avian influenza, Virus shedding, RT-PCR


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