©1996-2009 All Rights Reserved. Online Journal of Bioinformatics . You may not store
these pages in any form except for your own personal use. All other usage or
distribution is illegal under international copyright treaties. Permission to
use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJB publications. This
article may be copied once but may not be, reproduced or
re-transmitted without the express permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:To link to this page or any pages linking to this page you must link
directly to this page only here rather than put up your own page.
OJB®
Online Journal of Bioinformatics ©
7 (1) : 35-45, 2006
Comparative structure analysis of chorismate synthase
Marla S , Yalamanchili HK, Gelli P,
Singh HK, Praveen G, Ghatta G, Srikanth
S, Goutham K.
Biotechnology and Bioinformatics Department, JayaPrakash University of Information technology, Solan, H.P.173215,
ABSTRACT
Marla S , Yalamanchili
HK, Gelli P, Singh HK, Praveen G, Ghatta G, Srikanth S, Goutham K, Comparative structure analysis of Chorismate synthase, Online J
Bioinformatics, 7 (1) : 35 - 45,
2006. This work compares chorismate synthase structure in various microorganisms. The enzyme is essential
in the shikomate pathway in
bacteria, fungi and plants, but not in mammals. It is a useful target for drug
design inhibiting functional pathways with
chemotherapeutic effects. Binding of essential co-factors Flavin
mononucleotide (FMN) and 5-enolpyruvil shikomate-3-phosphate(EPSP)
affects its activity. The results of FMN
structure analysis and in various microorganisms are presented. Comparative
modeling and extent of structure similarities
between H. pyroli
and P. rumnicola
were performed using alpha and beta fold patterns, FMN binding and main chain
configuration residues. Active sites for binding of FMN
were detected. Phylogeny analysis was evaluated in various
microorganisms.
Key words: Chorismate
synthase, flavin
mononucleotide, Binding sites, Helicobacter pyroli, Prevotella rumnicola.