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Online Journal of Veterinary Research

 (Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 25 (12):836-838, 2021.

Immunogenicity of Streptococcus equi with or without S. equisimillis vaccine in horses.


Sohail Manzoor, Zahid Hussain, Sajjad-ur-Rahman, Muhammad Ashraf, Muhammad Mukhtar.


Civil Veterinary Hospital. Veterinary Disease Diagnostic Laboratory Faisalabad, Army Veterinary and Remount Depot Sargodha Pakistan.




Manzoor S, Hussain Z, Rahman S, Ashraf M, Mukhtar M., Immunogenicity of Streptococcus equi and S. equisimillis vaccine in horses, Onl J Vet Res., 25 (12):836-838, 2021. We report immunogenicity of inactivated vaccines of Streptococcus equi with or without Streptococcus equisimillis in horses. In one trial, 2 groups of 5 horses each were injected subcutaneously 1.0ml formalized whole cell culture broth of 4X107 ml Streptococcus equi or S. equisimillis boosted at day 14th. Antibody geometric mean titers (GMT) were determined by hem-agglutination after 28 days. In a 2nd trial Streptococci were killed in 10% formalin washed 3X in PBS at pH 7.2 injected 0.2ml SC in 3 groups of 5 horses each with 4x107, 4x109 and 4x1011/ml of S. equi with S. equisimillis. In both trials, 5 controls were not injected. In horses given 4X107 ml S equi GMT titers reached 7 by day 14 and 13.9 at 28 days. In those given 4X107 ml S equisimillis these values were 6.5 and 13. In horses given 2x107 of both isolates GMT reached 11.3, 2x109 or 2x1011 reached 14.7 by day 28. Findings suggest that streptococci were antigenic and immunogenic and may boost antibodies to strangles in horses .


Keywords: Strangle, Immune Response, Streptococcus equi, Streptococcus equisimillis