©1996-2019.
All Rights Reserved. Online Journal of Veterinary Research.
You may not store these pages in any form except for your own personal use. All
other usage or distribution is illegal under international copyright treaties. Permission to use any of these pages in any other way besides the
before mentioned must be gained in writing from the publisher. This
article is exclusively copyrighted in its entirety to OJVR. This article may be
copied once but may not be, reproduced or re-transmitted without the express
permission of the editors. This journal satisfies the refereeing requirements
(DEST) for the Higher Education Research Data Collection (Australia). Linking:
To link to this page or any pages linking to this page you must link directly
to this page only here rather than put up your own page.
OJVRTM
Online Journal of Veterinary Research©
Volume 20(8):526-532, 2016.
Effects of bone marrow and hydroxyapatite activated
heterologous platelet rich plasma
on healing of stifle joint osteo-arthritis
in rabbits.
Yalda Jalali
Khalilabadi1 DVM,
Seifollah N. Dehghani2, DVM,
MVSC, Fatemeh Namazi3, DVM, PhD.
1International
Division, Shiraz University, 2Department of Surgery and 3Department
of Pathology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
ABSTRACT
Khalilabadi
YJ, Dehghani SN, Namazi F., Effects of bone marrow and hydroxyapatite
activated heterologous platelet rich plasma on healing of stifle joint osteo-arthritis in rabbits, Onl J
Vet Res., 20(8):526-532, 2016. Effects
of heterologous platelet rich plasma (PRP) and its activation by hydroxyapatite
(HA) and bone marrow (BM) cells on healing of cartilage in rabbit stifle joint
is described. Left
stifle joint trochlear ridge of the femur of groups of White New Zealand
rabbits was exposed and 5x5 mm cartilage was curetted. The joint was then
washed, and capsule and skin sutured. Twenty four hours after surgery, groups
of 7 rabbits each received
1ml PRP in the joint, 1ml PRP and 0.2ml HA suspension, 1ml PRP or
0.2ml BM suspension. Controls were operated but not treated. Rabbits were then monitored 60 days,
euthanized, and the distal part of femur harvested for pathology. Kruskal Wallis analysis suggested that rabbits
given PRP with BM or HA had significant differences
in cartilage thickness and pathology compared with controls.
_____________
Key words. Platelet Rich Plasma, Hidroxyapatite, Bone Marrow, Repair of cartilage loss,
Rabbit.