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Online Journal of Veterinary Research©
Volume 24(10): 608-612, 2020.
Effect of splenomegaly and splenectomy on hematology in thalassemia patients.
Amal Hesham Hameed, Heba Saleh Shaheed
Al-Mustaqbal University College, Department of Medical Laboratory Techniques, Baghdad, Iraq
Hameed AH, Shaheed HS., Effect of splenomegaly and splenectomy on hematology in thalassemia patients. Onl J Vet Res., 24(10): 608-612, 2020. We determined hematology in sixty eight 9 to 15 years male patients with Thalassemia with splenomegaly (n=24) or splenectomy (n=44). Mean + SD white and red blood cells, lymphocytes, platelets and hemoglobin were determined by CBC device (Genex, USA). In patients with splenomegaly we found normal white cell counts (7.3 X 106/ml) but in those with splenectomy was ~52% higher (15.3 X 106/ml) (P < 0.01). Similarly lymphocytes were 2.8 X 106/ml being normal in splenomegaly but ~53% higher 6.06 X 106/ml in patients with spleens excised (P < 0.05). Hemoglobin was below normal values in both cases (7.02) and (7.33 g/dl) Mean platelets were 58% higher in splenectomy patients (P < 0.01). RBC counts declined below normal 3.32 + 0.98 and 2.98 + 0.86 X 1012/ml in both groups. Results suggest that splenectomy in Thassalemia patients may incur more serious hematological consequences than leaving enlarged spleens intact.
Key words : Hematology, Thalassemia, splenomegaly, Splenectomy.