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OJVRTM
Online Journal of Veterinary
Research©
Established 1994
ISSN 1328-925X
Volume 22 (8):692-702, 2018.
Effect of bone marrow mesenchymal
stem cell scaffold on functional recovery from acute spinal cord injury in
dogs.
Salah HA AL-Ameri1 and Hameed AK AL-Timmemi2
1Department(s) of Surgery and Obstetrics, College(s)
of Veterinary Medicine, University of Al- Qasim
Green, 2University
of Baghdad, Iraq.
ABSTRACT
Salah
HA AL-Ameri and Hameed AK AL-Timmemi.,
Effect of bone marrow mesenchymal stem cell scaffold on functional recovery
from acute spinal cord injury in dogs, Onl J Vet
Res., 22 (8):692-702, 2018. Spinal cord injury (SCI) causes
permanent neurological problems that in severe cases may lead to complete palsy.
Groups of 6 pound dogs each were subjected to left lateral section of the spinal
cord at the lumbar vertebrae (L2) under anesthesia. One group was then
implanted with an 50 µl culture medium of 5x106 bone marrow mesenchymal stem
cell scaffold seeded by 0.01mg urinary bladder sub mucosa powder into
the sectioned site. Controls were treated with phosphate buffer saline. Dogs
were euthanized at 112 days after section. We monitored improved somatosensory parameters and hind limb
performance from the sectioned site by Tarlov and Texas Spinal
Cord Injury Scale compared with saline controls (P≤0.05).
Compared with saline controls, we observed reduced tissue loss from secondary
processes, diminished glial scarring tissue, prominent re-myelination of regenerative
nerve fibers and remarkable angiogenesis.
Keywords: Canine, Spinal cord injury, Scaffold
and BMSC, functional Recovery, Regeneration.