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Online Journal of Veterinary Research©
Volume 22 (8):692-702, 2018.
Effect of bone marrow mesenchymal stem cell scaffold on functional recovery from acute spinal cord injury in dogs.
Salah HA AL-Ameri1 and Hameed AK AL-Timmemi2
1Department(s) of Surgery and Obstetrics, College(s) of Veterinary Medicine, University of Al- Qasim Green, 2University of Baghdad, Iraq.
Salah HA AL-Ameri and Hameed AK AL-Timmemi., Effect of bone marrow mesenchymal stem cell scaffold on functional recovery from acute spinal cord injury in dogs, Onl J Vet Res., 22 (8):692-702, 2018. Spinal cord injury (SCI) causes permanent neurological problems that in severe cases may lead to complete palsy. Groups of 6 pound dogs each were subjected to left lateral section of the spinal cord at the lumbar vertebrae (L2) under anesthesia. One group was then implanted with an 50 µl culture medium of 5x106 bone marrow mesenchymal stem cell scaffold seeded by 0.01mg urinary bladder sub mucosa powder into the sectioned site. Controls were treated with phosphate buffer saline. Dogs were euthanized at 112 days after section. We monitored improved somatosensory parameters and hind limb performance from the sectioned site by Tarlov and Texas Spinal Cord Injury Scale compared with saline controls (P≤0.05). Compared with saline controls, we observed reduced tissue loss from secondary processes, diminished glial scarring tissue, prominent re-myelination of regenerative nerve fibers and remarkable angiogenesis.
Keywords: Canine, Spinal cord injury, Scaffold and BMSC, functional Recovery, Regeneration.