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OJVRTM
Online Journal of Veterinary Research©
Volume (10):961-976, 2019
Effect of Spinacia
oleracea leaf extract on hypomagnesemia markers
in female Wistar rats
Mustafa Majid Obaid and Luma Waleed Khaleel.
Department of Physiology, Biochemistry and
Pharmacology, College of Veterinary Medicine, University of Baghdad.
ABSTRACT
Obaid MM, Khaleel LW., Effect
of Spinacia oleracea leaf
extract on hypomagnesemia markers in female Wistar
rats, Onl J Vet Res., (10):961-976, 2019. Four groups of 10 rats each were gavaged 1.39mg/kg Potassium chloride (KCL) daily for 56
days (1), KCL with 250mg/kg spinach (Spinacia
oleracea) (SO) extract (2), 250mg/kg SO (3) or KCL with 0.1mg Magnesium sulphate (MSO) (4).
Ten controls were gavaged distilled water. Fasting
cardiac blood was aspirated at 56 day for magnesium (Mg+2),
potassium (K+2), calcium (Ca+2), lactate dehydrogenase
(LDH) and troponin-1. At sacrifice we excised heart and bone tissue for
microscopy. Compared with controls, in rats gavaged
KCL, we found large declines (P <0.005) in Mg+2 (~-35%) and Ca+2
(~-51%) and increases in LDH (26%), K+2 (~16%) and troponin (~82%) (P < 0.05). In those given KCL with extract we found no
significant variation. In rats given only extract we found slight increases in
Mg and falls in Ca. In rats given KCL we observed hemorrhages, edema and
necrosis in myocardiac muscle fibers. We also
observed congestion in rats given KCL with extract but found no lesions in those
given only extract. In hypo-magnesemic rats we observed
longitudinal cracks in bone.
Key
Words: Potassium chloride, Toxicity, Spinacea, rats. Raw data provided.
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