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OJVRTM
Online Journal of
Veterinary Research©
Volume 18(5): 438-447, 2014. Redacted 2017
Effects of Zataria multiflora Boiss
extract on epididymal
sperm quality following
long term administration of copper sulfate in NMRI mice
Jalil Abshenas,
Ehsanollah Sakhaee, Fatemeh Mirzabeigi.
Department of Clinical Sciences,
School of Veterinary Medicine, Shahid Bahonar University of Kerman, Kerman, Iran
ABSTRACT
Abshenas J, Sakhaee E, Mirzabeigi
F., Effects of Zataria multiflora Boiss
extract on epididymal sperm quality following long
term administration of copper sulfate in NMRI mice, Onl
J Vet Res., 18(5): 438-447, 2014. Four groups of 12 mice each were gavaged 200mg/kg copper sulfate in 0.2 ml water, 400ppm Z.
multiflora extract daily in drinking water, gavaged
200 mg/kg/day copper sulfate in 0.2 ml water with 400 ppm Z multiflora per day
for 6 weeks or gavaged distilled water (controls). At
42 days mice were anesthetized by
diethyl ether and sacrificed by cervical dislocation. The left testes were
removed for histopathological evaluations. Administration of copper caused a
significant decrease in the sperm count, viability and motility at 42 days
compared to controls. However, a complete recovery in sperm count was observed
in mice given both copper and Z. multiflora at 42 days compared with
controls A partial improvement was observed in viability and motility
(p<0.001) values. Results suggest that Z. multiflora may ameliorate
effects of copper toxicity in testicular tissue.
Keywords:
Copper poisoning . Zataria
multiflora .
Sperm quality. Mice.
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