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Online Journal of Veterinary Research

(Including Medical and Laboratory Research)

Established 1994
ISSN 1328-925X


Volume 26 (10): 731-738, 2022.

Effect of jujube and lemon balm extracts on lead toxicity in testes of balb-c mice


Mohammad Alimoradi, Reza Khodarahmi, Zahra Alimoradi, Kamran Mansouri.


Medical Biology Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran




Alimoradi M, Khodarahmi R, Alimoradi Z, Mansouri K., Effect of jujube and lemon balm extracts on lead toxicity in testes of balb-c mice, Onl J Vet Res., 26 (10): 731-738, 2022. We report effect of antioxidant jujube and lemon balm powder extracts on testicular lead toxicity in balb-c mice. Groups of 10 adult mice each were gavaged lead acetate 7 days with (1) or without 200mg/kg extracts (2) in basal diet daily for 25 days and 1000ppm lead acetate in drinking water 7 days followed by 200mg/kg extract (3) for 25 days. Controls were given saline (4). Compared with controls, we found that mice gavaged extracts had increased (P < 0.05) weight for body 13%, testes 24% and epididymis 29% without microscopic differences. However, compared with those given lead acetate 7 days with extract there were no weight differences or microscopy. In mice gavaged lead acetate, we observed congestion, irregular germinal cells with amyloid and degenerated seminiferous tubules. whereas as those given extract testes and epidimis appeared normal. Results support previous findings in mice given these extracts.


Key words: Lead, extract Melissa officinalis and Ziziphus jujube, Mice, Testis and Epididymis.