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OJVRTM
Online Journal of Veterinary Research©
Volume
24 (5):284-289, 2020.
Effects of silymarin
supplement on antibody titers in broilers vaccinated against Newcastle and Avian influenza.
Hosseinian
SA, Abdi-Hachesoo B, Hashemi
Hazaveh SA
Department of Clinical Science, School of Veterinary Medicine, Shiraz
University, Shiraz, Iran
ABSTRACT
Hosseinian SA, Abdi-Hachesoo B, Hashemi Hazaveh SA., Effects of
silymarin supplement on antibody titers in
broilers vaccinated against Newcastle
and Avian influenza, Onl J Vet Res., 24 (5):284-289, 2020. We
describe effect of silymarin supplement given with mash
or pellet diets on antibody titers in broilers injected Newcastle and avian flu
vaccines. Groups of 20 day old Arbor Acre chicks were given basal mash, pellet
with or without 500 or 2500ppm silymarin diets daily
for 42 days. Birds were vaccinated Newcastle via eye drop at Day 8 with Hichner B1 strain, and subcutaneous inactivated Newcastle
and Influenza La Sota with H9N2 strains. Blood was
taken at 21, 28, 35 and 42 for antibody titers. Compared with mash and pellet controls
we found ~21-46% and ~22-41% increases (P < 0.05), respectively, in Newcastle
virus disease antibody titers in broilers given 500-2500 ppm silymarin supplements. Concerning avian flu antibody titers,
compared with mash controls, we found no change in antibody titers in birds
given 500ppm silymarin . However in those given 2500ppm same titers
increased (P < 0.05) ~28-42%. Compared with pellet controls avian flu
titers increased 17-40% in those given 500-2500 ppm silymarin.
Antibody titers for both vaccines peaked
by 28 and 35 days in all birds. Results suggest that silymarin
may enhance antibody titers to Newcastle’s and avian flu vaccine. Greater pellet
digestibility compared with mash may have increased availability of silymarin.
Key words: broilers, diet forms, immune response, silymarin.
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