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Online Journal of Veterinary Research©
Volume 23 (12):1195-1211, 2019.
Effect of silver nanoparticle supplement on mycotoxicity in Ross 308 broilers.
Jawad BJ and ALwan MJ.
Department of Veterinary Pathology, College of Veterinary Medicine, University of Baghdad, Iraq.
Jawad BJ, Alwan MJ., Effect of silver nanoparticle supplement on mycotoxicity in Ross 308 broilers, Onl J Vet Res., Onl J Vet Res., 23 (12):1195-1211, 2019. We evaluated effect of silver nanoparticle supplement on mycotoxicity markers in Ross broilers. Three groups of 5 seven day old chicks each were fed basal diet daily for 7 weeks mycotoxin AFB1= 10 ppb, Ochratoxin =1.4 ppb, T-2=129.9 ppb (Group 1), mycotoxins with 5 mg/Kg silver nanoparticles (2) or corn - soybean basal diet (Controls). Thirty days after treatment, blood was taken for TNF-α, IL 10, phagocytosis tests and glutathione peroxidase. Chicks were weighed every 7 days, then sacrificed at 7 weeks for bursal, spleen weight and histopathology. Compared with chicks given mycotoxin feed, body weights in those supplemented nanoparticles were 11-22% greater and 21-40% in basal diet controls (21-40%) (P < 0.05). At 30 days, serum TNF-α was 43% higher in those given nanoparticle supplement and 33% in controls (P < 0.05) but we found no differences in TLF-1. However, in those given nanoparticles serum gluthatione was 82% lower and in controls 56% lower. Bursae were 68% heavier with nanoparticles and 59% controls but Spleen weights 34 and 18% lower, respectively. We observed severe hemorrhage, necrosis, apoptosis, suppurative inflammation and mononuclear cell infiltration as well as depletion of lymphoid tissue in birds feed fed contaminated with mycotoxin but found milder lesions in those given nanoparticles.
Keywords: Mycotoxins, Silver Nanoparticles, Broiler Chicken, Glutathione Peroxidase. Raw data provided.