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Online Journal of Veterinary Research©
Volume 22 (7):608-614, 2018.
Effect of silver nanoparticles on healing of fractured ulna in rabbits.
Ali H. Saliem,* Orooba MS Ibrahim,* Sarwa Ibrahim Salih**
*Department of Physiology, Biochemistry and Pharmacology, **Department of Surgery and Obstetrics, College of Veterinary Medicine, Baghdad University, Iraq.
Saliem AH, Ibrahim OMS, Salih SI., Effect of silver nanoparticles on healing of fractured ulna in rabbits, 22 (7):608-614, 2018. Authors describe effect of silver nanoparticles (SNP) on healing of transverse diaphyseal ulnar fracture induced under anesthesia in rabbits. Groups of 10 male adult rabbits each, were treated at site of fracture with 0.5gm SNP powder sprinkled inside the fracture. Controls (n=10) were fractured but not treated with SNP. Subcutaneous tissue and skin was sutured and rabbits monitored daily for signs of fever, bone pain, swelling, and redness over the fracture site, unusual movement or mortality. Radiography was performed at 3 and 6 weeks after surgery and SNP treatment. Two days after ulnar fracturing, all rabbits exhibited normal signs and behavior. In controls, by 3 weeks we observed complete disappearance of radiographic fracture line bone union but periosteal reaction persisted and by 6 weeks there was complete union and ulna appeared normal. In rabbits treated with SNP by 3 weeks we observed radiographic line of fracture with callus not completely mineralized, and by 6 weeks, complete disappearance of fracture line bone union with cortico-medullary remodeling. The only difference we found with SNP was confined to a lack of periostal reaction compared with controls.
Keywords: silver nanoparticles, fracture, Ulna.