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OJBTM
Online Journal of Bioinformatics ©
Volume 9 (2): 113-120,
2008
Homology based
3D–structure modeling of glucose specific Sesbania stem lectin.
Saxena S, Das
HR, Das D, Biswas S
Proteomics and
Structural Biology Laboratory, Institute of Genomics and Integrative Biology,
ABSTRACT
Saxena S, Das
HR, Das D, Biswas S., Homology based 3D–structure modeling of glucose specific Sesbania
stem lectin, Online J Bioinformatics, 9 (2):113-120, 2008. The lectins from
legumes show a considerable sequence and structural homology but their
differences in carbohydrate specificity make them unique for studying structure
function relationships. 3D models of proteins were created to evaluate crystal
structure and function relationships. The 3D model of Sesbania bispinosa stem
lectin (STA) (Accession No.ABX59683.1) was vizualised
using web server Geno3D. Stereochemical properties were analyzed
using PROCHECK and generated models visualized with Rasmol
3D viewer and MolProbity for X-ray crystallography.
This study describes computer generated molecular models for which crystal
structures are not available.
Keywords: Homology modeling, Geno 3D, MolProbity,
Lectins, Sesbania
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