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OJVRTM

Online Journal of Veterinary Research©

 

Volume 26 (5): 323-330, 2022.

Effect of hypothalamus serotonin cannula  injection on bile secretion

serum lipids and liver enzymes in male Wistar rats.

 

Mona Rahdar1, Javad Sajedianfard1, Saeed Nazifi2, Fatemeh Azizi-Farsani1

 

1Department(s) of Physiology, 2Clinical Pathology, School of Veterinary Medicine, Shiraz University, Iran.

 

ABSTRACT

 

Mona Rahda, Javad Sajedianfard, Saeed Nazifi, Fatemeh Azizi-Farsani., Effect of hypothalamus serotonin cannula  injection on bile secretion serum lipids and liver enzymes in male Wistar rats, Onl J Vet Res., 26 (5): 323-330, 2022. The ventromedial hypothalamic nucleus (VMH) regulates gastrointestinal function and lipid metabolism. We report effect of serotonin 5-HT injection in VMH on bile secretion, serum lipids and hepatic enzymes in Wistar rats. Thirty male rodents were cannulated in VMH for serotonin and 1 week later in bile ducts for bile collected every 15 min for 60 min after injection. Blood was taken every 15 min for 60 min for serum biochemistry. Centrally applied 5-HT increased bile secretion at all studied periods and also decreased LDL-cholesterol (LDL-c) level. Present findings show that 5-HT participates in the central regulation of bile secretion in the rat, and VMH can be a special site for regulation of bile secretion and lipid levels.

 

Keywords: Serotonin, Bile flow, VMH, Serum lipids, Hepatic enzymes.

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