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OJVRTM
Online Journal of Veterinary Research©
Volume 26 (5): 323-330, 2022.
Effect of hypothalamus
serotonin cannula injection on bile secretion
serum lipids and liver enzymes in male Wistar rats.
Mona Rahdar1, Javad Sajedianfard1, Saeed Nazifi2, Fatemeh
Azizi-Farsani1
1Department(s) of Physiology, 2Clinical Pathology, School of Veterinary
Medicine, Shiraz University, Iran.
ABSTRACT
Mona Rahda,
Javad Sajedianfard, Saeed Nazifi, Fatemeh Azizi-Farsani., Effect of hypothalamus serotonin
cannula injection on bile secretion serum
lipids and liver enzymes in male Wistar rats, Onl J Vet Res., 26 (5):
323-330, 2022. The ventromedial hypothalamic
nucleus (VMH) regulates gastrointestinal function and lipid metabolism. We
report effect of serotonin 5-HT injection in VMH on bile secretion, serum
lipids and hepatic enzymes in Wistar rats. Thirty
male rodents were cannulated in VMH for serotonin and 1 week later in bile
ducts for bile collected every 15 min for 60 min after injection. Blood was
taken every 15 min for 60 min for serum biochemistry. Centrally applied 5-HT
increased bile secretion at all studied periods and also decreased
LDL-cholesterol (LDL-c) level. Present findings show that 5-HT participates in
the central regulation of bile secretion in the rat, and VMH can be a special
site for regulation of bile secretion and lipid levels.
Keywords: Serotonin, Bile flow, VMH, Serum lipids, Hepatic
enzymes.
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