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Online Journal of Veterinary Research©
Volume 26 (5): 323-330, 2022.
Effect of hypothalamic serotonin cannulation on bile secretion, serum lipids and liver enzymes in Wistar rats.
Mona Rahdar1, Javad Sajedianfard1, Saeed Nazifi2, Fatemeh Azizi-Farsani1
1Department(s) of Physiology, 2Clinical Pathology, School of Veterinary Medicine, Shiraz University, Iran.
Mona Rahda, Javad Sajedianfard, Saeed Nazifi, Fatemeh Azizi-Farsani., Effect of hypothalamic serotonin cannulation on bile secretion, serum lipids and liver enzymes in Wistar rats, Onl J Vet Res., 26 (5): 323-330, 2022. The ventromedial hypothalamic nucleus (VMH) regulates gastrointestinal function and lipid metabolism. We report effect of 1 µl/min 5-HT serotonin cannulation in VMH on bile secretion, serum lipids and hepatic enzymes in male Wistar rats. Groups of 10 male rodents were cannulated 1 µl/min 5-HT serotonin in VMH and 1 week later cannulated in ducts for bile every 15 min for 60 min after serotonin administration. Blood was taken every 15 min for 60 min for serum biochemistry. Centrally applied 5-HT increased bile secretion 22-31% over the 60 min and reduced sedrum LDL-cholesterol ~22%. We find that 5-HT serotonin may regulate hypothalamic regulation of bile secretion in rats.
Keywords: Serotonin, Bile flow, VMH, Serum lipids, Hepatic enzymes.