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Selection
pressure
analysis of African swine fever virus attachment protein p12
gene.
You-Fang
Chen1,
Youhua Chen2*
1School
of Software, Harbin Normal
University, Heilongjiang Province, China 2Department
of Renewable
Resources, University of Alberta, Edmonton, T6G 2H1, Canada
*Email: youhuach@gmail.com
ABSTRACT
Chen
YF,
Chen Y., Selection pressure analysis of African swine fever
virus
attachment protein p12 gene, Onl
J Bioinform., 14(2):207-212,
2013.
A
study to determine whether there is positive selection of the
attachment
protein p12 gene of African swine fever virus (ASFV) is
described. The functional
divergence among the sequences was very low as shown by
nucleotide diversity. It
was found that the gene is most likely undergoing purifying
selection instead
of positive selection. Through the likelihood-ratio test of
nested models, one positively
selected site 47D (in the template M84183) was identified by
Bayes Empirical
Bayes analysis but this was not statistically significant. In conclusion,
adaptive evolution is unlikely
for this structural gene.
KEYWORDS:
natural selection, structural
protein, adaptive evolution, Bayesian probability