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OJBTM
Online Journal of Bioinformatics ©
Volume
13 (1):103-119, 2012
EST
secretome analysis of Radopholus similis nematode.
Sangeetha
K.1, Rosana O. Babu1*, Santhosh J. Eapen2
1Bioinformatics Center, 2 Division of crop protection,
Indian Institute of Spices Research, Calicut, Kerala, India.
ABSTRACT
Sangeetha K, Babu RO,
Eapen SJ., EST secretome analysis of Radopholus similis nematode. Online J
Bioinform.,
13 (1):103-119, 2012. Plant
parasitic nematodes excrete or secrete (ES) various types of molecules in host
plants. The secretome of Radopholus similis could identify drug targets
and biomarkers for diagnostics or nematode survival factors. Patterns of gene
annotation and functional diversity of excretory/secretory proteins of
burrowing nematode (R. similis) were determined. Two hundred fourteen
secretory proteins of R similis were
identified. Forty six percent of gene ontology terms were associated with
biological processes, 38% with molecular function and 16% with cellular
components. InterProScan revealed EGF and IGFBP like domains. The role of
hypothetical proteins involved in signaling, metabolic and degradative pathways
and those preserved for R. similis species are described.
Keywords: Radopholus
similis, secretome analysis, Expressed Sequence Tags