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Online Journal of Veterinary Research©

(Including Medical and Laboratory Research)

Established 1994

ISSN 1328-925X


Volume 28(4): 208-215, 2024

Estrus in rats with diabetes mellitus.


 Murray LE, Dalal SJ, Rico PJ, Chenault VM


1 Department of Laboratory Animal Medicine, Uniformed Services University of the Health Sciences,, 2 Veterinary Medicine and Surgery Branch USAMRICD  and 4 U.S. Food and Drug Administration Center for Devices and Radiological Health Office of Science and Technology.




Murray LE, Dalal SJ,  Rico PJ, Chenault M, E Estrus in rats with diabetes mellitus, Onl J Vet Res 28(4): 208-215, 2024. Psammomys obesus fat sand rat is a wild desert rodent in the gerbil family that can develop diabetes when fed high calorie diets.  We compare low versus high calorie sand rat chow diets effects on estrous cycle length.  For this study we developed a vaginal epithelial cell classification to assist us to compare the length of the estrous cycle and vaginal cytology in the normal and diabetogenic sand rats.  We found estrous cycles over 10 day period 1.5±1.1 for normal and 1.6± 0.8 for diabetogenic sand rats and length of cycle 4.0±0.9 in normal and 4.8±0.7 days diabetogenic rats. Proestrus commenced with diminishing to few PMN’s and increasing numbers of parabasal cells.  Overall, a mixture of parabasal, intermediate cells and some squamous epithelial cells characterize proestrus.  Our data indicated that in both groups when parabasal cell numbers started to increase from 0 – 5 % to 30 % and above with corresponding decrease in neutrophils from 70-80 % to 50 % then proestrus ensued within 24 hrs. We found no statistically significant differences in estrous between any groups similar to those reported by others.  However, we described the vaginal cytology for the normal and diabetogenic sand rats for the different stages of the estrous cycle and found no significant difference in estrous cycle length. 


KEY WORDS: Sand Rat, Diabetes, Estrous Cycle.