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OJVRTM
Online Journal of Veterinary Research©
(Including
Medical and Laboratory Research)
Established
1994
ISSN
1328-925X
Volume 28(4): 208-215,
2024
Murray LE, Dalal
SJ, Rico PJ, Chenault VM
1
Department of Laboratory Animal Medicine, Uniformed Services
University of the Health Sciences,, 2 Veterinary Medicine and
Surgery Branch USAMRICD and 4 U.S.
Food and Drug Administration Center for Devices and Radiological Health Office
of Science and Technology.
SUMMARY
Murray LE, Dalal
SJ, Rico PJ, Chenault M, E
Estrus in rats with diabetes mellitus,
Onl J Vet Res 28(4): 208-215, 2024. Psammomys obesus fat sand rat is a wild desert rodent
in the gerbil family that can develop diabetes when fed high calorie
diets. We compare low versus high calorie sand rat chow diets effects on
estrous cycle length. For this study we developed a vaginal epithelial
cell classification to assist us to compare the length of the estrous cycle and
vaginal cytology in the normal and diabetogenic sand
rats. We found estrous cycles over 10 day period 1.5±1.1 for normal and
1.6± 0.8 for diabetogenic sand rats and length of
cycle 4.0±0.9 in normal and 4.8±0.7 days diabetogenic
rats. Proestrus commenced with diminishing to few
PMN’s and increasing numbers of parabasal
cells. Overall, a mixture of parabasal,
intermediate cells and some squamous epithelial cells characterize proestrus. Our data indicated that in both groups
when parabasal cell numbers started to increase from
0 – 5 % to 30 % and above with corresponding decrease in neutrophils from 70-80
% to 50 % then proestrus ensued within 24 hrs. We
found no statistically significant differences in estrous between any groups
similar to those reported by others. However, we described the vaginal
cytology for the normal and diabetogenic sand rats
for the different stages of the estrous cycle and found no significant
difference in estrous cycle length.
KEY WORDS: Sand Rat,
Diabetes, Estrous Cycle.
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