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OJVRTM
Online Journal of
Veterinary Research©
Volume 21(5):216-222, 2017.
Effect of Salvia
Officinalis on serum luteinizing, follicle stimulating, and testosterone
hormones in adult male Wistar rats with multiple
sclerosis
Mona Khajehee, MinaTadjalli.
Department of Anatomy
and Embryology, Faculty of Veterinary Science, Shiraz University, Shiraz, Iran
ABSTRACT
Khajehee M, Tadjalli M., Effect
of Salvia Officinalis on serum luteinizing, follicle stimulating, and
testosterone hormones in adult male Wistar rats with
multiple sclerosis, Onl J Vet Res., 21(4):216-222,
2017. Multiple Sclerosis (MS) is an inflammatory disease of
the central nervous system with multifocal areas of demyelination. Effects of 400 and 600mg/kg Salvia Officinalis (SO) gavaged to groups of 6 rats each with or without MS on serum Luteinizing (LH),
follicle stimulating (FSH) and testosterone hormones are
described.
Controls were rats with or without MS gavaged SO or
not treated. MS was induced with 0.2% Cuprizone
in feed confirmed by Kerschensteiner’s daily clinical
score test.
Blood taken from the heart was used to determine serum LH, FSH and
testosterone. Serum LH, FSH and testosterone levels in MS controls and those with MS, were lower compared with healthy controls or those
without MS. Hormones in mice without MS, increased compared with healthy
controls, whereas in those with MS, increased compared with MS controls. Results suggest that SO
may affect serum LH, FSH and testosterone in rats with MS.
Key-Words: Salvia officinalis, Multiple sclerosis, rats.