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Online Journal of Veterinary Research©
Volume 22 (6):501-512, 2018.
Effect of Salvia officinalis with Bifidobacterium longum supplements on serum lipid and liver histology in male albino Wistar rats.
Russell Abdulridah Issa; Jafar Abbas Al-Maamori and Zainab Naashat Al-Saadi
Department of Biology, College of Sciences, University of Wasit, Iraq.
Issa RA, Al-Maamori JA, Al-Saadi ZN., Effect of Salvia officinalis with Bifidobacterium longum supplements on serum lipid and liver histology in male albino Wistar rats. Onl J Vet Res., 22 (6):501-512, 2018. We report effect of sage tea (S. officinalis L.) with bacterial suspension of Bifidobacterium longum probiotic on serum lipid profile in male Wistar rats. Groups of 6 rats each were fed standard diet (controls) and atherogenic diet daily for 28 days. Other rats were fed atherogenic diet supplemented with gavaged 0.086mtg/kg sage tea with 1ml of 0.5 per 1×108 CFU/1ml Bifidobacterium longum daily for 14 (n=6) or 28 (n=6) days. Compared with controls, body weights increased in those fed fatty atherogenic diet but in those given supplement for 28 days reduced body weight (P < 0.05) but not if given for only 14 days. However, the supplement for 14 days reduced (P < 0.05) serum trigliceride (TG) and very low density lipid (VLDL), and given for 28 days, reduced total cholesterol, TG, low density lipoprotein and VLDL but increased high density lipoprotein (HDL). Compared with standard diet controls, in livers of rats given the fatty diet we observed congestion of blood vessels and fat deposit in connective tissue. In those supplemented 28 days livers appeared normal. We find that sage tea (S. officinalis L.) with bacterial suspension of Bifidobacterium longum probiotic supplementation given daily for 28 days reduces dyslipidemia induced by atherogenic diet in rats.
Key words: Salvia officinalis, Bifidobacterium longum, probiotic, lipid profile.